Effect of amino acids on inhibition of lactate dehydogenase-X by gossypol

Experimental and Molecular Medicine

Volumn 31, Issue 1, 1999, Pages 25-29

  Javed, Masood H ^a   Khan, Mehtab A ^b  

^a AGA KHAN UNIVERSITY   (Pakistan)

^b PAF Base   (Pakistan)

Author keywords

Amino acids; Goat; Gossypol acetic acid; LDH X; Testes

Indexed keywords

AMINO ACID; ARGININE; CYSTEINE; GLUTAMIC ACID; GLYCINE; GOSSYPOL ACETIC ACID; HISTIDINE; LACTATE DEHYDROGENASE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; VALINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PURIFICATION; GOAT; MICHAELIS MENTEN KINETICS; NONHUMAN; SPECIES DIFFERENCE; TESTIS;

ANIMALIA; CAPRA HIRCUS;

EID: 0033620387     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1999.4     Document Type: Article

References (17)

1. Camp, K. V. and Sande, M. V. (1988) LDH isoenzymes in prostate and testis of wild animals and some histological remarks. Urol. Res. 16: 373-375
2. Dai, R. X. and Pan, S. Y. (1980) Studies on the antifertility effect of gossypol. VI. Observations of testicular atrophy of rats administered gossypol for long terms. Acta. Expt. Biol. Sonica. 13: 192-199
3. Gavella, M. and Cvitkovic, P. (1985) Semen LDH-X deficiency and male infertility. Arch. Androl. 15: 173-176
4. Gupta, G. S., Kapur, S. and Kinsky, R. G. (1988) Inhibition kinetics of LDH isoenzymes by gosspol acetic acid. Biochem. Int. 17: 25-34
5. Hahn, D. W., Rusticus, C., Homn, R. and Johnson, A. N. (1981) Antifertility and endocrine activities of gossypol in rodents. Contraception 24: 97-105
6. Javed, M. H. and Waqar, M. A. (1995) Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. Biochem. Soc. Trans. 23: 626S
7. Javed, M. H., Yousuf, F. A, Hussain, A. N., Ishaq, M. and Wqar, M. A. (1995) Purification and properties of LDH from liver of Uromastix hardwickii. Comp. Biochem. Physiol. 111B: 27-34
8. Javed, M. H., Azimuddin, S. M. I., Hussain, A. N., Ahmed, A. and Ishaq, M. (1997) Purification and characterization of LDH from varanus liver. Exp. Mol. Med. 31: 25-30
9. Kocha, T., Fukuda, T., Isobe, T. and Okuyama, T. (1990) Large scale purification of bovine brain lactate dehydrogenase by affinity chromatography on immobilized colchicine. J. Biochem. 107: 138-143
10. Lowry, O. H., Rosenbrough, N. J., Farr, A. L. and Randall, R. (1951) Protein measuement with folin phenol reagent. J. Biol. Chem. 193: 265-275
11. 4) impairs fertilization in vivo. Am. J. Reprod. Immunol. 24: 1-8
12. Morris, I. D., Haggins, C. and Matlin, S. A. (1986) Inactivation of testicular LDH-X from laboratory animals and man by gossypol and its isomers. J. Reprod. Fert. 77: 607-612
13. Qian, S. Z. (1984) Gossypol: a potential antifertility agent for males. Ann. Rev. Pharmacol. Toxicol. 24: 329-360
14. Singh, P. P., Singh, V .N. and Sirmour, S. K. (1995) Estrogen dependent LDH-Y, a new LDH isozyme and fertility factor in mice uterus during early pregnancy. Horm. Metab. Res. 27: 182-184
15. 4 in human seminal plasma and its relationship to testicular function: methodological aspect. Int. J. Andrology 8: 193-200
16. Wang, Y. E., Luo, Y. D. and Tang, X. C. (1979) Studies on the antifertility action of cotton seed meal and gossypol. Acta Pharm. Sinica 14: 662-669
17. Zhi-Ping, G., Yi-Xing, W., Goo-Wei, S., Wei-Chang, W., Zhen-Xing, C., Xiu-Juan, Z., Qin-Xiang, S. and Yu, J. (1990). Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. Int. J. Androl., 13: 253-257