Is the gut responsible for multiple organ failure?

Schweizerische Medizinische Wochenschrift

Volumn 129, Issue 43, 1999, Pages 1600-1604

  Bion, J F ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Gut; Multiple organ failure; Splanchnic region

Indexed keywords

IMMUNOLOGIC AGENT;

CELL ADHESION; CELL DAMAGE; CELL MIGRATION; CONFERENCE PAPER; CRITICAL ILLNESS; CYTOTOXICITY; DEFENSE MECHANISM; DISEASE PREDISPOSITION; IMMUNOTHERAPY; INTESTINE ISCHEMIA; LEUKOCYTE ACTIVATION; MULTIPLE ORGAN FAILURE; OXYGEN SUPPLY; TARGET ORGAN;

DIGESTIVE SYSTEM; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MULTIPLE ORGAN FAILURE; POSTOPERATIVE COMPLICATIONS; WOUNDS AND INJURIES;

EID: 0033619478     PISSN: 00367672     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (23)

1. Knaus WA, Draper EA, Wagner DP, Zimmermann JE. Prognosis in acute organ-system failure. Ann Surg 1985; 202:685-93.
2. Sage WM, Rosenthal MH, Silverman JF. Is intensive care worth it? - An assessment of input and outcome for the critically ill. Crit Care Med 1986;14:777-82.
3. Baue AE, Multiple, progressive, or sequential systems failure: a syndrome of the 1970s. Arch Surg 1975;110:779-81.
4. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma 1995;38:185-93.
5. Meakings JL, Marshall JC. The gut as the motor of multiple system organ failure. In: Marston A, Bulkley GB, FiddianGreen RG, Haglund UH, editors. Splanchnic ischaemia and multiple organ failure. London: Edward Arnold; 1989.
6. Manji M, Wilson P, Gosling P, Keogh B, Bion JF. Comparing measures of intestinal permeability. Intensive Care Med 1997;23:S87.
7. Unno N, Menconi MJ, Smith M, Fink MP. Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 1995;23:1170-6.
8. Krause W, Matheis H, Wulf K. Fungaemia and funguria after oral administration of Candida albicans. Lancet 1969; 1(7595):598-9.
9. Biffl WL, Moore EE. Splanchnic ischaemia/reperfusion and multiple organ failure. Br J Anaesth 1996;77:59-70.
10. Riddington DW, Venkaresh B, Boivin C, Bonser RS, Elliott TSJ, Marshall T, et al. Intestinal permeability, gastric intramucosal pH and systemic endotoxaemia in patients undergoing cardiopulmonary bypass. JAMA 1996;275:1007-12.
11. Maynard N, Bihari D, Beale R, Smithies M, Baldock G, Mason R, et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993;270:1203-10.
12. Gutierrez G, Palizas F, Doglio G, Wainsztein N, Gallesio A, Pacin J, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992;339:195-9.
13. Older P, Smith R, Courtney P, Hone R. Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise. Chest 1993;104:701-4.
14. Shoemaker WC, Appel PL, Kram HB, et al. Prospective trial of supranormal values of survivors as therapeutic goals in high-rish surgical patients. Chest 1988;94:1176-86.
15. Bishop MH, Shoemaker WC, Appel PL, et al. Prospective randomised trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 1995;38:780-7.
16. Boyd O, Grounds RM, Bennett ED. A randomised clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993;270:2699-707.
17. Hayes MA, Timmins AC, Yau EH, Palazzo M, Watson D, Hinds CJ. Oxygen transport pattern in patients with sepsis syndrome or septic shock: influence of treatment and relationship to outcome. Crit Care Med 1997;25:926-36.
18. 2 Collaborative Group. N Engl J Med 1995;333:1025-32.
19. Bennett-Guerrero E, Ayuso L, Hamilton-Davies C, et al. Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. JAMA 1997; 277:646-50.
20. Westendorp RGJ, Langermans JAM, Huizinga TWJ, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170-3.
21. Sorensen TIA, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988;318:727-32.
22. Gallacher T, Manji M, Blyden S, Hallissey M, Nash G, Bion J. Presurgery L-selectins are associated with subsequent complications in elective oesophagectomy patients. Intensive Care Med 1997;23:S33.
23. Montgomery HE, Marshall R, Hemingway H, et al. Human gene for physical performance. Nature 1998;393(6682): 221-2.