BOMI - A novel peptide coupling reagent

Tetrahedron Letters

Volumn 40, Issue 18, 1999, Pages 3605-3608

  Li, Peng ^a   Xu, Jie Cheng ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY DERIVATIVE; BENZOTRIAZOL 1 YLOXY N,N DIMETHYLMETHANIMINIUM HEXACHLOROANTIMONATE; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DECOMPOSITION; PEPTIDE SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS;

EID: 0033617325     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00536-5     Document Type: Article

References (16)

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4. (d) S. Q. Chen; J. C. Xu, Chinese Journal of Chemistry, 1995, 13, 175-189.
5. 4OSb: C, 20.54; H, 2.09; N, 10.65. Found: C, 20.78, H, 2.12; N, 10.63.
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11. 8. Van der Auwera, C.; Van Damme, S.; Anteunis, M. J. O. Int. J. Pept. Protein Res. 1987, 29, 464-471.
12. 9. The two diastereometric tripeptides, Z-Gly-L-Phe-Val-OMe and Z-Gly-D-Phe-Val-OMe, can be easily separated by HPLC and monitored at 220 nm. The extent of racemization was determined by measuring the ratio of peak areas between Z-Gly-D-Phe-Val-OMe and Z-Gly-L-Phe-Val-OMe. The reaction speed and yield were also determined by measuring the ratio of peak areas between products and internal standard, Boc-Phe-Val-OMe, during different time periods of reaction, Z-Gly-DL-Phe-Val-OMe was used as reference compound to correct the molar ratio of LL and DL isomers.
13. 1H-NMR, FAB-MS, IR.
14. 11. T. Karayannis; L.P. Gerothanassis, Biopolymers 1990, 29, 423-439.
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16. +).