New high loading paramagnetic support for solid phase organic chemistry

Tetrahedron Letters

Volumn 40, Issue 18, 1999, Pages 3531-3534

  Sucholeiki, Irving ^a   Perez, J Manuel ^a  

^a Solid Phase Sciences Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; ARTICLE; FILTRATION; IMMUNOASSAY; ORGANIC CHEMISTRY; POLYMERIZATION; SERODIAGNOSIS; SOLID PHASE EXTRACTION; SPECTROPHOTOMETRY; SYNTHESIS;

EID: 0033617264     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00558-4     Document Type: Article

References (14)

1. 1. For a recent review see: Hall, S.E. in Annual Report in Combinatorial Chemistry and Molecular Diversity, Vol. 1, (Moos, W.H.; Pavia, M.R.; Kay,B.K.; Ellington, A.D., editors), Escom Sciences Publishers, Leiden, 1997, 30-40.
2. 2. Gayo, L.M.; Suto, M.J. Tetrahedron Lett. 1997, 38, 513.
3. 3. Siegel, M.G.; Hahn, P.J.; Dressman, B.A.; Fritz, J.E.; Grunwell, J.R.; Kaldor, S.W. Tetrahedron Lett. 1997 38, 3357.
4. 4. Kaldor, S.W.; Siegel, M.G.; Fritz, J.E.; Dressman, B.A.; Hahn, P.J. Tetrahedron Lett. 1996, 37, 7193.
5. 5. Matte, C.; Muller, A. 1994, US 5,318,914.
6. 6. Szymonifka, M.J.; Chapman, K.T. Tetrahedron Lett. 1995, 36, 1597.
7. 7. Benner, S.A. 1987, US 4,638,032.
8. 8. A low cross-linked polystyrene bead (1-2% divinyl benzene) can be seen as a sponge with the majority (>95%) of the reactive sites located within the cavities of the bead. Solvents such as methylene chloride cause the cavities within the bead to greatly expand, allowing reagents and starting materials to freely enter and leave the bead through the process of diffusion.
9. 9. Sucholeiki, I.; Margetts, G.; Roberts, M. 1998, US 5,834,121.
10. 10. Sucholeiki, I., 1997, US 5,684,130.
11. 11. The level of substitution was determined by iodine elemental analysis.
12. 12. The reaction was followed by taking aliquots at timed intervals and separating the components using reversed-phase HPLC (C-18 radial compression column) and 254 nm detection.
13. 13. The loading capacity was determined to be 0.6 mmoles amine/gram by spectrophotometric assay of the released fluorenylmethoxycarbonyl (Fmoc) group according to Green, J.; Bradley, K. Tetrahedron 1993, 49, 4141.
14. 4·1.35 TFA: C, 41.50; H, 5.91; N, 14.48; F, 15.91. Found: C, 41.17; H, 5.80; N, 12.98; F, 15.87.