The study of candidate genes in drug trials: Sample size considerations

Statistics in Medicine

Volumn 18, Issue 6, 1999, Pages 741-751

  Elston, Robert C ^a   Idury, Ramana M ^b   Cardon, Lon R ^b   Lichter, Jay B ^b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Axys Pharmaceuticals Inc   (United States)

^c Genset Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG RESPONSE; DRUG SCREENING; GENETIC VARIABILITY; GENETICS; SAMPLE; STATISTICAL ANALYSIS;

CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; DRUG EVALUATION; GENES; GENETIC TECHNIQUES; PHARMACOKINETICS; SAMPLE SIZE;

EID: 0033616910     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0258(19990330)18:6<741::AID-SIM64>3.0.CO;2-U     Document Type: Article

References (6)

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4. Schork, N. J. and Weder, A.B. 'The use of genetic information in large-scale clinical trials: Applications to Alzheimer research', Alzheimer Disease and Associated Disorders, 10, 22-26 (1996).
5. Schlesselman, J. J. Case-Control Studies, Oxford University Press, New York, 1982.
6. Umbach, D. M. and Weinberg, C. R. 'Designing and analyzing case-control studies to exploit independence of genotype and exposure', Statistics in Medicine, 16, 1731-1743 (1997).