Copper (I) mediated highly diastereoselective conjugate addition of Grignard reagents to functionalised 6-membered ring cycloalkenols. Synthesis of cyclohexanes derivatives substituted on three contiguous atoms

Tetrahedron Letters

Volumn 40, Issue 5, 1999, Pages 871-874

  Dambrin, Valéry ^a   Villiéras, Monique ^a   Lebreton, Jacques ^a   Toupet, Loïc ^b   Amri, Hassen ^c   Villiéras, Jean ^a  

^a Centre National de la Recherche Scientifique   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

Author keywords

2 Hydroxycyclohexane carboxylates; 2 Silyloxycyclohexene carboxylates; Conjugate Addition; Copper catalysed Grignard reactions; Diastereoselectivity; Ketene acetals; Michael reactions

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; COPPER ION; CYCLOHEXANE DERIVATIVE; REAGENT;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CRYSTAL STRUCTURE; DRUG CONJUGATION; DRUG SYNTHESIS; HYDROLYSIS; REACTION ANALYSIS; STEREOISOMERISM;

EID: 0033613771     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02543-X     Document Type: Article

References (19)

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15. 3 and extraction with diethyl ether finally furnished β-silyloxy ester. The last deprotection step was accomplished according to known procedures (see 9 and 10).
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