Corticosteroids alter G protein inwardly rectifying potassium channels protein levels in hippocampal subfields

Brain Research

Volumn 839, Issue 2, 1999, Pages 331-335

  Muma, Nancy A ^a   Beck, Sheryl G ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adrenalectomy; Corticosteroid; Corticosterone; GIRK; Glucocortico id; Glucocorticoid; Hippocampus; Immunoblot; Mineralocorticoid; Rat

Indexed keywords

BRAIN PROTEIN; BRAIN RECEPTOR; CORTICOSTEROID; CORTICOSTERONE; GLUCOCORTICOID; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROCORTISONE; ION CHANNEL; MINERALOCORTICOID; NEUROTRANSMITTER; POTASSIUM CHANNEL;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SECOND MESSENGER; STRESS;

ADRENALECTOMY; ALDOSTERONE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN CHEMISTRY; DENTATE GYRUS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEINS; HYDROCORTISONE; IMMUNOBLOTTING; MALE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033612893     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01754-0     Document Type: Article

References (26)

1. B receptors to the same channels in hippocampus. Science. 234:1986;1261-1265.
2. 1A receptor-mediated hyperpolarization in area CA1 hippocampal pyramidal neurons. Neuropsychopharmacology. 14:1996;27-33.
3. Burgess L.H., Handa R.J. Chronic estrogen-induced alterations in adreno-corticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats. Endocrinology. 131:1992;1261-1269.
4. Doupnik C.A., Davidson N., Lester H.A. The inward rectifier potassium channel family. Current Opinion in Neurobiology. 5:1995;268-277.
5. + channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 94:1997;7070-7075.
6. 1A responsiveness in CA1 pyramidal neurons by in vivo activation of corticosteroid receptors. J. Neuroendocrinol. 8:1996;433-438.
7. Jacobson L., Sapolsky R.M. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocrinol. Rev. 12:1991;118-134.
8. Jöels M., de Kloet E.R. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog. Neurobiol. 43:1994;1-36.
9. Jöels M., Hesen W., de Kloet E.R. Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons. J. Neurosci. 11:1991;2288-2294.
10. + channel mRNAs are differentially expressed in the adult rat brain. J. Neurosci. 16:1996;3559-3570.
11. + channel in the rat. FEBS Letters. 348:1994;139-144.
12. T. Kenakin, Pharmacological Analysis of Drug-Receptor Interactions, Lippincott-Raven, Philadelphia, PA, 1993.
13. + channels are activated by Gbg subunits and function as heteromultimers. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6542-6546.
14. + channels in the brain. FEBS Letters. 353:1994;37-42.
15. + channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. The Journal of Neuroscience. 16:1996;7137-7150.
16. McEwen B.S., de Kloet E.R., Rostene W. Adrenal steroid receptors and actions in the nervous system. Physiological Reviews. 66:1986;1121-1188.
17. 1A mediated hyperpolarization in CA1 hippocampal pyramidal cells. Society for Neuroscience Abstracts. 22:1997;2349. Abstract.
18. 1A receptor linked to inward-rectifying potassium current in hippocampal CA3 pyramidal cells. J. Neurophysiol. 71:1994;2161-2167.
19. 1A receptor-effector pathway in hippocampal subfield CA3 pyramidal cells. J. Pharmacol. Exp. Ther. 284:1998;1227-1233.
20. Okuhara D.Y., Beck S.G., Muma N.A. Corticosterone alters G protein a-subunit levels in the rat hippocampus. Brain Res. 745:1997;144-151.
21. + channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain. The Journal of Neuroscience. 16:1996;1990-2001.
22. Reul J.M., van den Bosch F.R., de Kloet E.R. Differential response of type I and type II corticosteroid receptors to changes in plasma steroid level and circadian rhythmicity. Neuroendocrinology. 45:1987;407-412.
23. Reul J.M., van den Bosch F.R., de Kloet E.R. Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications. Journal of Endocrinology. 115:1987;459-467.
24. + channel Kir3.1 (KCNJ3/GIRK1). Genomics. 39:1998;279-288.
25. Sheppard K.E., Funder J.W. Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: direct binding studies. Journal of Steroid Biochemistry. 28:1987;737-742.
26. + channel (GIRK4) from human hippocampus associates with other GIRK channels. J. Neurosci. 16:1996;930-938.