A change in scientific approach: From alternation to randomised allocation in clinical trials in the 1940s

British Medical Journal

Volumn 319, Issue 7209, 1999, Pages 572-573

  D'Arcy Hart, P ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; PATULIN; PLACEBO; STREPTOMYCIN;

ARTICLE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG SCREENING; DRUG TOXICITY; HEALTH CARE ORGANIZATION; HISTORY OF MEDICINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICAL RESEARCH; PATIENT SELECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TUBERCULOSIS;

ANTIBIOTICS, ANTITUBERCULAR; COMMON COLD; CONTROLLED CLINICAL TRIALS; HISTORY, 20TH CENTURY; HUMANS; PATULIN; RANDOMIZED CONTROLLED TRIALS; STREPTOMYCIN; TUBERCULOSIS;

EID: 0033612867     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. 1 MRC Patulin Clinical Trials Committee. Clinical trials of patulin in the common cold. Lancet 1944;ii:373-5.
2. 2 Clark M. Random thoughts. The evolution of modern clinical trials. Medical Research Council New 1998;79:24-6.
3. 3 MRC Streptomycin in Tuberculosis Trials Committee. Streptomycin treatment of pulmonary tuberculosis. BMJ 1948;ii:769-83.
4. 4 Landsborough Thomson A. Half a century of medical research. London: HMSO, 1975:238-9.
5. 5 Armitage P. Bradford Hill and the randomised controlled trial. Pharm Med 1992;6:23-37.
6. 6 Sutherland I. Medical Research Council streptomycin trial. In: Encyclopaedia of biostatistics. Chichester: Wiley, 1998:2559-62.
7. 7 Bradford Hill A. Memories of the British streptomycin trial in tuberculosis. Controlled Clin Trials 1990;11:77-90.