An isonitrile-alkyne cascade to di-substituted indoles

Tetrahedron Letters

Volumn 40, Issue 35, 1999, Pages 6325-6327

  Rainier, Jon D ^a   Kennedy, Abigail R ^a   Chase, Eric ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; INDOLE DERIVATIVE; ISONITRILE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION;

EID: 0033609901     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01169-7     Document Type: Article

References (24)

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6. Intramolecular isonitrile-alkyne couplings have been utilized by the Curran group. See: (a) Curran, D. P.; Liu, H. J. Am. Chem. Soc. 1991, 113, 2127.
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12. 3SnH see: Enholm, E. J.; Whitley, P. E. Tetrahedron Lett. 1996, 37, 559, and references contained within.
13. 16
14. 2
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17. Thus far, we have used diethyl amine, aniline, benzyl amine, and methanol.
18. 4
19. 5
20. For the addition of thiol-radicals to isonitriles, see: Bachi, M. D.; Balanov, A.; Bar-Ner, N. J. Org. Chem. 1994, 59, 7752.
21. +): 323.1198; found: 323.1192.
22. We have utilized 10 in carbon-carbon bond forming reactions with nucleophiles; this work will be communicated shortly
23. Thorand, S.; Krause, N. J. Org. Chem. 1998, 63, 8551.
24. Obrecht, R.; Hermann, R.; Ugi, I. Synthesis 1985, 4, 400.