Mass-spectrometric evaluation of HLA-A*0201-associated peptides identifies dominant naturally processed forms of CTL epitopes from MART-1 and gp100

International Journal of Cancer

Volumn 82, Issue 5, 1999, Pages 669-677

  Skipper, Jonathan C A ^a   Gulden, Pamela H ^a   Hendrickson, Ronald C ^a   Harthun, Nancy ^a   Caldwell, Jennifer A ^a   Shabanowitz, Jeffrey ^a   Engelhard, Victor H ^a,b   Hunt, Donald F ^a   Slingluff Jr , Craig L ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A ANTIGEN; MART1 ANTIGEN; MELANOCYTE LINEAGE SPECIFIC ANTIGEN GP100; MELANOCYTE LINEAGE-SPECIFIC ANTIGEN GP100; MEMBRANE PROTEIN; PEPTIDE; TUMOR ANTIGEN; TUMOR PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; CELL CULTURE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; EVALUATION; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY; MELANOMA; METABOLISM; PROTEIN PROCESSING; SYNTHESIS; CROSS REACTION; HLA SYSTEM; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA CELL; MULTIGENE FAMILY; PRIORITY JOURNAL;

ANTIGENS, NEOPLASM; EPITOPES, T-LYMPHOCYTE; EVALUATION STUDIES; HLA-A ANTIGENS; HUMANS; MASS SPECTROMETRY; MELANOMA; MEMBRANE GLYCOPROTEINS; NEOPLASM PROTEINS; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0033609729     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(19990827)82:5<669::aid-ijc9>3.0.co;2-%23     Document Type: Article

References (14)

1. BARKER, A.B., SCHREURS, M.W., DE BOER, A.J., KAWAKAMI, Y., ROSENBERG, S.A., ADEMA, G.J. and FIGDOR, C.G., Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. exp. Med., 179, 1005-1009 (1994).
2. BAKKER, A.G., SCHREURS, M.W., TAFAZZUL, G., DE BOER, A.J., KAWAKAMI, Y., ADEMA, G.J. and FIGDOR, C.G., Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1-restricted anti-melanoma CTL line. Int. J. Cancer. 62, 97-102 (1995).
3. BRICHARD, V., VAN PEL, A., WÖLFEL, C., DE PLAEN, E., LETHÉ, B., COULIE, P. and BOON, T., The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 178, 489-495 (1993).
4. + cytotoxic T lymphocytes. J. exp. Med., 181, 363-368 (1995).
5. COULIE, P.G., BRICHARD, V., VAN PEL, A., WÖLFEL, T., SCHNEIDER, J., TRAVERSARI, C., DE PLAEN, E., LURQUIN, C., SZIKORA, J.-P., RENAULD, J.-C. and BOON, T., A new gene encoding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 180, 35-42 (1994).
6. COX, A.L., SKIPPER, J., CHEN, Y., HENDERSON, R.A., DARROW, T.L., SHABANOWITZ, J., ENGELHARD, V.H., HUNT, D.F. and SLINOLUFF, C.L., Jr., Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science, 264, 716-719 (1994).
7. ENGELHARD, V.H. and 13 OTHERS, Mass spectrometric analysis of peptides associated with the human class I MHC molecules HLA-A2.1 and HLA-B7 and identification of structural features that determine binding. Chem. Immunol., 57, 39-62 (1993).
8. HOUNSELL, E.F., DAVIES, M.J. and RENOUF, D.V., O-linked protein glycosylation structure and function. Glycoconjugate J., 13, 19-26 (1996).
9. JAEGER, E., BERNHARD, H., ROMERO, P., RINGHOFFER, M., ARAND, M., KARBACH, J., ILSEMANN, C., HAGEDORN, M. and KNUTH, A., Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma-associated antigens. Int. J. Cancer, 66, 162-169 (1996).
10. KAWAKAMI, Y., ELIYAHU, S., DELGADO, C.H., ROBBINS, P.F., RIVOLTINI, L., TOPALIAN, S.L., MIKI, T. and ROSENBERG, S.A., Cloning of the gene coding for shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. nat. Acad. Sci. (Wash.), 91, 3515-3519 (1994a).
11. KAWAKAMI, Y., ELIYAHU, S., JENNINGS, C., SAKAGUCHI, K., KANG, X., SOUTHWOOD, S., ROBBINS, P.F., SETTE, A., APPELLA, E. and ROSENBERG, S.A., Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating lymphocytes associated with in vivo tumor regression. J. Immunol., 154, 3961-3968 (1995).
12. KAWAKAMI, Y., ELIYAHU, S., SAKAGUCHI, K., ROBBINS, P.F., RIVOLTINI, L., YANELLI, J.R., APPELLA, E. and ROSENBERG, S.A., Identification of the immunodominant peptides of the MART-1 human melanoma antigen on melanoma cells results from post-translational modification. J. exp. Med., 183, 527-534 (1996a).
13. SKIPPER, J.C.A., KITTLESEN, D.J., HENDRICKSON, R.C., DEACON, D.D., HARTHUN, N.L., WAGNER, S.N., HUNT, D.F., ENGELHARD, V.H. and SLINGLUFF, C.L., Jr., Shared epitopes for HLA-A3 restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100. J. Immunol., 157, 5027-5033 (1996b).
14. SLINGLUFF, C.L., JR., COX, A.L., HENDERSON, R.A., HUNT, D.F. and ENGELHARD, V.H., Recognition of human melanoma cells by HLA-A2.1 restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes. J. Immunol. 150, 2955-2963 (1993).