Enantioselective synthesis of (-)-Bifurcadiol: A natural antitumor marine product

Tetrahedron Letters

Volumn 40, Issue 48, 1999, Pages 8359-8360

  Guardia, Stéphane Di ^a   Valls, Robert ^a   Mesguiche, Véronique ^a   Brunel, Jean Michel ^b   Culioli, Gérald ^c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Ecole Centrale Marseille   (France)

^c UNIVERSITÉ DE TOULON   (France)

Author keywords

( ) Bifurcadiol; Alkylation; Asymmetric reduction; Marine natural product

Indexed keywords

ALLYL COMPOUND; BIFURCADIOL; NITRILE; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; ENANTIOMER; REDUCTION; STEREOCHEMISTRY;

EID: 0033607724     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01726-8     Document Type: Article

References (16)

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5. -1. See: Zee, O. P.; Kim, D. K.; Choi, S. U.; Lee, C. O.; Lee, K. R. Arch. Pharmacal. Res. 1999, 22, 225-227.
6. The (+)-TADDOL used is the (4S,5S)-2,2-dimethyl-α,α,α′,α′-tetraphenyldioxolane-4,5-dimethanol.
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10. (a) Hertenstein, U.; Hünig, S.; Öller, M. Synthesis 1976, 416-417.
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15. -1 and retention time of 10.2 min.
16. The (-)-TADDOL used is the (4R,5R)-2,2-dimethyl-α,α,α′,α′-tetraphenyldioxolane-4,5-dimethanol.