Efficacy of an ovine caseous lymphadenitis vaccine formulated using a genetically inactive form of the Corynebacterium pseudotuberculosis phospholipase D

Vaccine

Volumn 17, Issue 7-8, 1999, Pages 802-808

  Hodgson, Adrian L M ^a   Carter, Kylie ^b   Tachedjian, Mary ^a   Krywult, Jolanta ^a   Corner, Leigh A ^c   McColl, Malcolm ^b   Cameron, Anthony ^b  

^a CSIRO   (Australia)

^b CSL LIMITED   (Australia)

^c MASSEY UNIVERSITY   (New Zealand)

Author keywords

Mutagenesis; Toxoid; Vaccine

Indexed keywords

BACTERIAL ENZYME; BACTERIAL VACCINE; CASEOUS LYMPHADENITIS VACCINE; EXOTOXIN; FORMALDEHYDE; GLANVAC; HISTIDINE; PHOSPHOLIPASE D; RECOMBINANT VACCINE; SERINE; TOXOID; UNCLASSIFIED DRUG;

ANIMAL DISEASE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM; DRUG EFFICACY; DRUG FORMULATION; ENZYME ACTIVE SITE; FEMALE; GENE EXPRESSION SYSTEM; GENE INACTIVATION; IMMUNE RESPONSE; LYMPHADENITIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SHEEP; SITE DIRECTED MUTAGENESIS; SUBCUTANEOUS DRUG ADMINISTRATION; SUPERNATANT; VACCINE PRODUCTION;

ANIMALS; BACTERIAL VACCINES; COLONY COUNT, MICROBIAL; CORYNEBACTERIUM INFECTIONS; CORYNEBACTERIUM PSEUDOTUBERCULOSIS; ENZYME ACTIVATION; FEMALE; FORMALDEHYDE; LYMPHADENITIS; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASE D; PLASMIDS; SHEEP; SHEEP DISEASES; VACCINES, INACTIVATED; VACCINES, SYNTHETIC;

EID: 0033605092     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00264-3     Document Type: Article

References (24)

1. Paton M. Control of cheesy gland in sheep. West Aust J Agric. 34:1993;31-37.
2. Batey R.G. Pathogenesis of caseous lymphadenitis in sheep and goats. Aust Vet J. 63:1986;169-272.
3. Hodgson A.L.M., Krywult J., Corner L.A., Rothel J.S., Radford A.J. Rational attenuation of Corynebacterium pseudotuberculosis. Infect Immun. 60:1994;2900-2905.
4. Carne H.R., Onon E.O. Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels. Nature. 271:1978;246-366.
5. Titball R.W. Bacterial phospholipases C. Microbiol Rev. 57:1993;347-366.
6. Eggleton D.G., Haynes J.A., Middleton H.D., Cox J.C. Immunisation against caseous lymphadenitis: correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in combined clostridial-corynebacterial vaccines. Aust Vet J. 68:1991;322-325.
7. Hodgson A.L.M., Tachedjian M., Corner L.A., Radford A.J. Protection of sheep against caseous lymphadenitis using a single oral dose of live recombinant Corynebacterium pseudotuberculosis. Infect Immun. 62:1994;4275-5275.
8. McNarmara P.J., Bradley G.A., Songer J.G. Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis. Mol Microbiol. 12:1994;921-930.
9. Johnson V.G., Nicholls P.J. Identification of a single amino acid substitution in the diphtheria toxin A chain of CRM 228 responsible for the loss of enzymatic activity. J Bacteriol. 176:1994;4766-4769.
10. Pizza M., Covacci A., Bartoloni A. Mutants of pertussis toxin suitable for vaccine development. Science. 246:1989;497-500.
11. Tachedjian M., Krywult J., Moore R.J., Hodgson A.L.M. Caseous lymphadenitis vaccine development: site-specific inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene. Vaccine. 13:1995;1785-1792.
12. Quentin-Millet M.J., Arminjon F., Danve B., Cadoz M., Armand J. Acellular pertussis vaccines: evaluation of reversion in a nude mouse model. J Biol Stand. 16:1988;99-108.
13. Douglas C.M., Collier R.J. Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity. J Bacteriol. 169:1987;4967-4971.
14. Rappuoli R., Podda A., Pizza M. Progress towards the development of new vaccines against whooping cough. Vaccine. 10:1992;1027-1032.
15. Radford A.J., Hodgson A.L.M. Construction and characterisation of a Mycobacterium-Escherichia coli shuttle vector. Plasmid. 25:1991;149-153.
16. Zhang Y., Praszkier J., Hodgson A.L.M., Pittard J. Molecular analysis and characterisation of a broad host-range plasmid pEP2. J Bacteriol. 176:1994;5718-5728.
17. Souckova A., Soucek A. Inhibition of the hemolytic action of alpha and beta lysins of Staphylococcus pyogenes by Corynebacterium hemolyticum, C. ovis and C. ulcerans. Toxicon. 10:1972;501-509.
18. Zaki M.M. Production of a soluble substance by Corynebacterium ovis. Nature (London). 205:1987;928-929.
19. Haynes J.A., Tkalcevic J., Nisbet I.T. Production of an enzymatically inactive analog of phospholipase D from Corynebacterium pseudotuberculosis. Gene. 119:1992;119-121.
20. Eggleton D.G., Middleton H.A., Doidge C. V, Minty D.W. Immunisation against ovine caseous lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial cells. Aust Vet J. 68:1991;317-319.
21. Pepin M., Paton M., Hodgson A.L.M. Pathogenesis and epidemiology of Corynebacterium pseudotuberculosis infection in sheep. Curr Topics Vet Res. 1:1994;63-82.
22. Chilton F.M. Assays for measuring arachidonic acid release from phospholipids. Methods Enzymol. 197:1991;166-182.
23. Cameron AJ, McColl ML. A new generation CLA vaccine. Proc. Australian Sheep Veterinary Society, AVA Conference. Canberra, 1994. p. 41-3.
24. Burnette W.N., Mar V.L., Platler B.W. Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Infect Immun. 59:1991;4266-4270.