Studies on the mechanism of action of 2-formyl-4-pyrrolidinopyridine: Isolation and characterization of a reactive intermediate

Journal of Organic Chemistry

Volumn 64, Issue 13, 1999, Pages 4652-4664

  Sammakia, Tarek ^a   Hurley, T Brian ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 4 NITROPHENOL; ESTER; KETONE; METHANOL; PYRIDINE DERIVATIVE;

ACYLATION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION KINETICS; LYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0033603507     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo982281n     Document Type: Article

References (48)

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18. 4-methanol we do not detect the hemiacetal corresponding to 5, demonstrating the lower electrophilicity of the 3-carboxaldehyde. Compounds 7 and 8 exist as 1:1 and 6:1 ratios of hemiacetal to aldehyde, respectively, indicating that the ability of the aldehyde to reversibly form a hemiacetal is not a sufficient condition for catalysis.
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