Amidine protection for solution phase library synthesis

Tetrahedron Letters

Volumn 40, Issue 26, 1999, Pages 4847-4850

  Bailey, Christine ^a   Baker, Emma ^a   Hayler, Judy ^a   Kane, Peter ^a  

^a NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N (4 METHOXYBENZYLOXYCARBONYL) 6 AMIDINONAPHTH 2 YLOXY]BUT 2 ENOATE; 4 METHOXYBENZYL 4 NITROPHENYLCARBONATE; AMIDINE; AMIDINONAPHTHOL; CARBONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHROMATOGRAPHY; HYDROGEN BOND; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SYNTHESIS;

EID: 0033603448     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00891-6     Document Type: Article

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16. 4), evaporated to dryness and pumped under high vacuum for 4 hrs to afford 4-methoxybenzyl-4-nitrophenylcarbonate 7 (10.29g, 93.7%), one spot on tic (EtOAc/hexane 1:1)
17. 1H (400MHz) (MeOD)δ 1.3 (t, J = 7Hz, 3H), 4.2 (q, J = 7Hz, 2H), 4.92 (m, 2H), 6.22 (dt, J=15.8 & 2Hz, 1H) 7.16 (dt, J=15.8 & 4.1Hz, 1H) 7.38 (dd, J=9.15Hz & 2.5Hz, 1H) 7.41 (d, J=2Hz, 1H) 7.77 (dd, J=8.7Hz & 2Hz, 1H) 7.99 (dd, J=8.7 & 2Hz, 1H) 8.01 (dd, J=8.7 & 5.85Hz 1H) 8.37 (d, J=2Hz, 1H)