A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran.

Tetrahedron Letters

Volumn 40, Issue 52, 1999, Pages 9383-9384

  Twyman, Lance J ^a   Allsop, David ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Amyloid; Alzheimer's disease; Benzofurans; Heterocyclic; Intramolecular Wittig reaction

Indexed keywords

AMYLOID PROTEIN; BENZOFURAN DERIVATIVE; HETEROCYCLIC COMPOUND; PROTEIN AGGREGATION INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL REACTION; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN AGGREGATION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0033601421     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02030-4     Document Type: Article

References (9)

1. Kakizuka, A. Trends Genet. 1998, 14, 396.
2. Hardy, J.; and Allsop, D. Trends Pharmacol. Sci. 1991, 12, 383.
3. (a) Allsop, D.; Howlett, D.; Christie, G.; and Karran, E. Biochem. Soc. Trans. 1998. 26, 459.
4. (b) Howlett, D.R.; Allsop, D.; and Karran, E.H. Neurobiology of Akheimer's Disease (Dawbarn D. & Allen S.J.; editors). 1999, pp. 9-49, Bios Scientific Publishers, Oxford. In press.
5. Howlett, D.R.; Perry, A.E.; Godfrey, F.; Swatton, J.E.; Jennings, K.H.; Spitzfaden, C.; Wadsworth, H.; Wood, S.J.; and Markwell, R.E. Biochem. J. 1999, 340, 283.
6. Brenner, L. M.; and Brush, C. K. United States patent. 1997, no 4,001,426.
7. Arcadi, A.; Mainelli, F.; and Cacchi, S. Synthesis. 1986, 9. 449. and references therein.
8. Hercouet, A.; and Le Corre, M. Tetrahedron Lett. 1979, 23, 2145.
9. +.