A new cyclopeptide alkaloid from the bark of Waltheria douradinha

Tetrahedron Letters

Volumn 40, Issue 52, 1999, Pages 9205-9209

  Morel, Ademir F ^a   Flach, Adriana ^a   Zanatta, Nilo ^a   Ethur, Eduarde M ^a   Mostardeiro, Marco A ^a   Gehrke, Ilaine T S ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b Depto de Biologia e Quim   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; AMINO ACID; CYCLODEXTRIN; CYCLOPEPTIDE; UNCLASSIFIED DRUG; WALTHERINE C;

ARTICLE; BRAZIL; DRUG ISOLATION; PLANT; STEREOCHEMISTRY;

EID: 0033601401     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01821-3     Document Type: Article

References (12)

1. Schultz, A. R. H. Introdução à Bolânica Sistemática, UFRGS, ed.; Porto Alegre: Brazil, 1980; Vol. 2.
2. Simões, C. M. O. Plantas da Medicina Popular do Rio Grande do Sul, UFRGS, ed.; Porto Alegre: Brazil, 1986.
3. Morel, A. F.; Gehrke, I. T. S.; Mostardeiro, M. A.; Ethur, E. M.; Dessoy, E. C. Phytochemistry 1999, 51, 473.
4. Sanders, J. K. M.; Hunter, B. K. Modern NMR Spectroscopy: A Guide for Chemists; Oxford University Press: Oxford, 1993; 2nd ed.
5. Morel, A. F.; Bravo, R. V. F.; Reis, F. D. A. M.; Ruveda, E. A. Phytochemistry 1979, 18, 473.
6. Voelter, W.; Morel, A. F. Z. Naturforsch 1987, 42b, 467.
7. Morel, A. F.; Dessoy, E. S. M.; Moreira, J. J.; Meneses, A. S.; Mostardeiro, M. A.; Zanatta, N.; Wessjohann, L. A. Phytochemistry 1998, 1, 125.
8. Sierra, G. M.; Mascaretti, A. O.; Diaz, F. J.; Ruveda, E. A. J. Chem. Soc., Chem. Commun. 1970, 653.
9. Chiral GLC analyses were carried out on a Varian 3800, equipped with a flame ionization detector using 0.25 i.d. fused silica capillaries coated with 2,6-methyl-3-pentyl-β-cyclodextrine, diluted with the polysiloxane OV 1701. All amino acids used possess L- and D,L-configuration and are commercially available (Fluka/Aldrich/Sigma).
10. König, W. A.; Icheln, D.; Runge, T.; Pforr, I.; Krebs, A. J. High Resolut. Chromatogr. 1990, 13, 702.
11. Silva, U. F.; Cardoso, C. D.; Zanatta, N.; Morel, A. F. Phytochemical Analysis 1996, 7, 20.
12. 2O at 125°C for 20 h (for N,N-dimethyltryptophan). The acidic and basic solutions were concentrated and the residues were treated as described for amino acids, according to Ref. 11.