Clumsiness, confusion, coma, and valproate

Lancet

Volumn 353, Issue 9162, 1999, Pages 1408-

  Ellaway, C J ^a   Bennetts, B ^a   Tuck, R R ^b   Wilcken, B ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b The New Children's Hospital ^*

Author keywords

[No Author keywords available]

Indexed keywords

ORNITHINE CARBAMOYLTRANSFERASE; VALPROIC ACID;

ACRODYNIA; ADULT; ARTICLE; AUTOPSY; CASE REPORT; CEREBELLUM DEGENERATION; COMA; CONFUSION; CONSCIOUSNESS; GENE MUTATION; GENETIC DISORDER; HUMAN; HYPERAMMONEMIA; MALE; NAUSEA; NERVE BIOPSY; PAIN; PRIORITY JOURNAL; SURAL NERVE; UREA CYCLE; URINALYSIS; VOMITING;

EID: 0033599766     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)01433-6     Document Type: Article

References (5)

1. Hata A., Tsuzuki T., Shimada K., Takiguchi M., Mori M., Mastuda I. Structure of the human ornithine transcarbamylase gene. J Biochem. 103:1988;302-308.
2. Tuchman M., Morizono H., Rajagopal B.S., Plante R.J., Allewell N.M. Identification of "private" mutations in patients with ornithine transcarbamylase deficiency. J Inher Metab Dis. 20:1997;525-527.
3. Brusilow S., Horwich A.L. Urea cycle enzymes. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The Metabolic and Molecular Bases of Inherited Disease. 1995;1187-1221 McGraw-Hill, New York.
4. Kay J.D.S., Hilton-Smith D., Hyman N. Valproate toxicity and ornithine carbamoyltransferase deficiency. Lancet. ii:1986;1283-1284.
5. Honeycutt D., Callahan K., Rutledge L., Evans B. Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonaemia during initiation of valproate therapy. Neurol. 42:1992;666-668.