Acid base chemistry of the reaction of aromatic L-amino acid decarboxylase and dopa analyzed by transient and steady-state kinetics: Preferential binding of the substrate with its amino group unprotonated

Biochemistry

Volumn 38, Issue 47, 1999, Pages 15615-15622

  Hayashi, Hideyuki ^a   Tsukiyama, Fuyo ^a   Ishii, Seiji ^a   Mizuguchi, Hiroyuki ^a   Kagamiyama, Hiroyuki ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; DOPA; PYRIDOXAL 5 PHOSPHATE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MICHAELIS MENTEN KINETICS; NONHUMAN; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; RAT;

AMINATION; ANIMALS; AROMATIC-L-AMINO-ACID DECARBOXYLASES; BINDING SITES; DIHYDROXYPHENYLALANINE; HYDROGEN-ION CONCENTRATION; IMINES; KINETICS; LIVER; MODELS, CHEMICAL; PROTONS; RATS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY;

FELIS CATUS; MINO;

EID: 0033598686     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9909795     Document Type: Article

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