Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation

Lancet

Volumn 354, Issue 9188, 1999, Pages 1444-1445

  Ong, Y C ^a   Wong, H B ^a   Adaikan, G ^a   Yong, E L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; MUTANT PROTEIN; TESTOSTERONE;

ARTICLE; CASE REPORT; DRUG RECEPTOR BINDING; GENITAL MALFORMATION; HUMAN; INFANT; MALE; MALE GENITAL SYSTEM; MALE GENITAL TRACT MALFORMATION; PRIORITY JOURNAL; SEXUAL DEVELOPMENT; TOPICAL DRUG ADMINISTRATION;

EID: 0033598615     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)03205-5     Document Type: Article

References (5)

1. Hiort O., Huang Q., Sinnecker G.H.et al. Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counselling, and therapy. J Clin Endocrinol Metab. 77:1993;262-266.
2. Kazemi-Esfarjani P., Beitel L.K., Trifiro M.et al. Substitution of valine-865 by methionine of leucine in the human androgen receptor causes complete or partial androgen insensitivity, respectively with distinct androgen receptor phenotypes. Mol Endocrinol. 7:1993;37-46.
3. Grino P.B., Isidro-Gutierrez R.F., Griffin J.E., Wilson J.D. Androgen resistance associated with a qualitative abnormality of the androgen receptor and responsive to high dose androgen therapy. J Clin Endocrinol Metab. 68:1989;578-584.
4. Ghadessy F.J., Lim J., Abdullah A.A.et al. Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions. J Clin Invest. 103:1999;1517-1525.
5. Choi S.K., Han S.E., Kim D.H., de Ligneres B. Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. J Urol. 150:1993;657-660.