Titanocene-catalyzed asymmetric ketone hydrosilylation: The effect of catalyst activation protocol and additives on the reaction rate and enantioselectivity

Journal of the American Chemical Society

Volumn 121, Issue 24, 1999, Pages 5640-5644

  Yun, Jaesook ^a   Buchwald, Stephen L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE; TITANOCENE;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CHIRALITY; ENANTIOMER; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0033597622     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990450v     Document Type: Article

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13. -1). The absorbance of the C=O stretching decreased to baseline in 4 h, and the reaction was continued for another 2 h. There was no change in the intensity during the next 2 h. However, ketone was still detected by GC after hydrolysis of the reaction mixture, and the ratio of alcohol product and ketone was 98:2.
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