Novel cyclopropapyrroloindole derivative (AT-3510) bearing methoxycarbonyl and trifluoromethyl groups

Journal of Medicinal Chemistry

Volumn 42, Issue 8, 1999, Pages 1448-1458

  Fukuda, Yasumichi ^a   Furuta, Hirosuke ^a   Kusama, Yoshie ^a   Ebisu, Hiroyuki ^a   Oomori, Yasuo ^a   Terashima, Shiro ^b  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLOROMETHYL 1,4,5,6 TETRAHYDRO 6 [5 [(7 METHOXYBENZOFURAN 2 YLCARBONYL)AMINO] 1H INDOL 2 YLCARBONYL] 8 [(4 METHYL 1 PIPERAZINYLCARBONYL)OXY] 2 TRIFLUOROMETHYLPYRROLO[3,2 E]INDOLE 3 CARBOXYLIC ACID METHYL ESTER; CISPLATIN; INDOLE DERIVATIVE; METHYL 4 CHLOROMETHYL 6 [5 [(7 METHOXYBENZOFURAN 2 YLCARBONYL)AMINO] 1H INDOL 2 YLCARBONYL] 8 [(4 METHYLPIPERAZIN 1 CARBONYL)OXY] 2 TRIFLUOROMETHYL 1,4,5,6 TETRAHYDROPYRROLO[3,2 E]INDOLE 3 CARBOXYLATE HYDROCHLORIDE; PIBROZELESIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON ADENOCARCINOMA; DRUG STRUCTURE; DRUG SYNTHESIS; LEUKEMIA; MOUSE; NONHUMAN; SARCOMA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOFURANS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PRODRUGS; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0033594362     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980668c     Document Type: Article

References (27)

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