Homoisofagomines: Chemical-enzymatic synthesis and evaluation as α- and β-glucosidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 4, 1999, Pages 615-618

  Schuster, Matthias ^a  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; BETA GLUCOSIDASE; BETA GLUCOSIDASE INHIBITOR; FAGOMINE; FRUCTOSE BISPHOSPHATE ALDOLASE; HOMOISOFAGOMINE DERIVATIVE; NOJIRIMYCIN; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG STABILITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME MECHANISM; ENZYME SYNTHESIS; STEREOCHEMISTRY;

ALPHA-GLUCOSIDASES; BETA-GLUCOSIDASE; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PIPERIDINES;

EID: 0033593856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00042-6     Document Type: Article

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22. +) calcd. 162, obsd. 162.
23. M against [I].
24. 14. The 5-epimers of 4 and 5 were inactive against α-and β-glucosidase as to be expected. 5-epi-4 representing 2-homo-1-deoxy-manno-nojirimycin showed no activity against α-mannosidase from jack beans.