Synthesis of N2 (2-aminofluoren-3-yl) adducts of 2'-deoxyguanosine

Tetrahedron Letters

Volumn 40, Issue 4, 1999, Pages 597-598

  Bonala, Radha R ^a   Yu, Pei Lin ^a   Johnson, Francis ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORENYLAMINE; CARCINOGEN; DEOXYGUANOSINE DERIVATIVE; N2 (2 ACETYLAMINOFLUOREN 3 YL) 2' DEOXYGUANOSINE; N2 (2 AMINOFLUOREN 3 YL) 2' DEOXYGUANOSINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MUTAGENESIS; CHEMICAL REACTION; DNA ADDUCT; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0033593536     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02502-7     Document Type: Article

References (6)

1. Kriek, J.A.; Miller, W.J.; Miller, E.C.; Biochemistry, 1967,6, 177.
2. Kriek, E.; Cancer Research, 1972, 32, 2042.
3. Westra, J.G.; Kriek, E.; Hittenhausen, H.; Chem.Biol.Interact., 1976,15,149.
4. Compound 5 (68% yield) was obtained by boiling 2-amino-3-bromo-9-fluorenone with m-chloro perbenzoic acid (mCPBA, 50-60%, about 4eq.) in 1,2-dichloroethane for 8hrs.
5. 6-allyl derivative of 2'-deoxyxanthosine and has not been applied to the synthesis of 3b.
6. Edwards, C.; Boche, G.; Steinbrecher, T.; Scheer, S.; J.Chem.Soc., Perkin Trans. 1, 1997, 1887.