Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'- monophosphate (DM2-ddUMP): A potential ddUMP prodrug

Tetrahedron Letters

Volumn 40, Issue 4, 1999, Pages 607-610

  Khan, Saeed R ^a   Farquhar, David ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYURIDINE DERIVATIVE; BIS(N,N DIMETHYLCARBAMOYLOXYMETHYL) 2',3' DIDEOXYURIDINE 5' MONOPHOSPHATE; BIS(PIVALOYLOXYMETHYL) 2',3' DIDEOXYURIDINE 5' MONOPHOSPHATE; BUFFER; ESTERASE; PHOSPHODIESTERASE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG HALF LIFE; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; PLASMA;

EID: 0033593497     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02446-0     Document Type: Article

References (13)

1. Lieberman, K.C.; Heidelberger, C. J. Biol. Chem. 1955, 316, 823-830.
2. Roll, P.M; Weinfeld, H.; Carroll, E.; Brown, G.B. J. Biol. Chem. 1956, 220, 439-454.
3. Farquhar, D.; Srivastava, D. N.; Kuttesch, N. J.; Saunders, P. P. J. Pharm. Sci. 1983, 72, 324-325.
4. Khan, S.; Nowak, B.; Plunkett, W.; Farquhar, D. Proc. Am. Assoc. Cancer Res. 1990, 31, 425.
5. Sastry, K. J.; Nehete, P. N.; Khan, S.; Plunkett, W.; Arlinhaus, R. B.; Farquhar, D. Mol. Pharmacol. 1992, 41, 441-445.
6. Farquhar, D.; Khan, S.; Srivastva D. N.; Saunders, P. P. J. Med. Chem. 1994, 37, 3902-3909
7. Khan, S.; Farquhar, D. Manuscript is in preparation.
8. 2Cl) C, H, N.
9. 8P) C, H, N.
10. 8P) C, H, N.
11. 11P): C, H, N.
12. 1-ddUMP, ddU, and ddUMP were respectively 28.81, 25.31, 13.88, and 8.46 min.
13. 1-ddUMP, ddUMP, and ddU as described above.