Selective deprotection of alkyl t-butyldimethylsilyl ethers in the presence of aryl t-butyldimethylsilyl ethers

Tetrahedron Letters

Volumn 40, Issue 4, 1999, Pages 665-666

  Grieco, Paul A ^a   Markworth, Christopher J ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL ARYL ETHER; HYDROCHLORIC ACID; TERT BUTYLDIMETHYLSILYL ETHER DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; STEREOCHEMISTRY;

EID: 0033593311     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02499-X     Document Type: Article

References (5)

1. (a) Collington, E. W.; Finch, H.; Smith, I. J. Tetrahedron Lett. 1985, 26, 681.
2. (b) Lipshutz, B. H.; Keith, J. Tetrahedron Lett. 1998, 39, 2495.
3. (c) Oriyama, T.; Kobayashi, Y.; Noda, K. Synlett. 1998. 1047.
4. Lipshutz (reference 1b) has shown that exposure (<5 min) of a 0.1 M solution of 1 in MeOH containing one drop of 47% aqueous HI led to complete monodeprotection along with <5% of fully deprotected material.
5. This research was supported by a grant from the National Institute of General Medical Sciences (GM 33605).