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Murata, M.1
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5
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0001189336
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For an overview on the synthesis of Fischer carbene complexes see: E. O. Fischer, C. G. Kreiter, H. J. Kollmeier, J. Muller and R. D. Fischer, J. Organomet. Chem., 1971, 28, 237.
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Fischer, E.O.1
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6
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0000718155
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For the synthesis of alkynylboronates, see: H. C. Brown, N. G. Bhat and M. Srebnik, Tetrahedron Lett., 1988, 29, 2631.
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7
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0001448820
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W. D. Wulff, P. C. Tang and J. S. McCallum, J. Am. Chem. Soc., 1981, 103, 7677; K. H. Dötz, J. Muhlemeier, U. Schubert and O. Orama, J. Organomet. Chem., 1983, 247, 187; W. D. Wulff, K. S. Chan and P. C. Tang, J. Org. Chem., 1984, 49, 2293.
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Wulff, W.D.1
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8
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0001686194
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Dötz, K.H.1
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9
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0000123442
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W. D. Wulff, P. C. Tang and J. S. McCallum, J. Am. Chem. Soc., 1981, 103, 7677; K. H. Dötz, J. Muhlemeier, U. Schubert and O. Orama, J. Organomet. Chem., 1983, 247, 187; W. D. Wulff, K. S. Chan and P. C. Tang, J. Org. Chem., 1984, 49, 2293.
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10
-
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0344770010
-
-
note
-
Alkynylboronates are readily hydrolysed to the parent alkyne in the presence of protic reagents, (ref. 6), it is therefore plausible that the phenolic benzannulated product mediates alkyne protodeboronation. Indeed, hex-1-yne was recovered in the volatile material isolated from the reaction mixture in Table1, entry 1.
-
-
-
-
11
-
-
0344770009
-
-
note
-
in = 0.0932), final R = 0.0618, with allowance for the thermal anisotropy of all non-hydrogen atoms. CCDC 182/1418.
-
-
-
-
13
-
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0003633970
-
Anthracycline and anthracenedione - Based anti-cancer agents
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14
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0027285603
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J. P. A. Harrity, W. J. Kerr and D. Middlemiss, Tetrahedron Lett., 1993, 34, 2995.
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15
-
-
0344337958
-
-
note
-
The rigorous establishment of compounds 11 and 16 is ongoing but at present is assumed to follow the same insertion patterns as outlined in Scheme 4.
-
-
-
-
16
-
-
0344337957
-
-
note
-
The A value of the alkynyl substituent can often serve as a useful guide to predicting regioselectivity (ref. 10). In this context, studies are underway to determine the A value of a range of boronie ester moieties and will be the subject of a future disclosure.
-
-
-
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17
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0001565242
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P. Hofmann, M. Hämmerle and G. Unfried, New J. Chem., 1991, 15, 769.
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18
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0000023285
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19
-
-
0345632449
-
-
note
-
4: C, 70.80; H, 8.20. Found: C, 70.67; H, 8.36%).
-
-
-
-
20
-
-
0025055455
-
-
1H spectra of 4 were identical to an authentic sample prepared from hex-1-yne: A. Yamashita, S. Ayako, R. G. Schaub, M. K. Bach, G. J. White and A. Toy, J. Med. Chem., 1990, 33, 775.
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Yamashita, A.1
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Toy, A.6
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