Delineation of a neutralizing subregion within the immunodominant epitope (GH loop) of foot-and-mouth disease virus VP1 which does not contain the RGD motif

Vaccine

Volumn 18, Issue 1-2, 1999, Pages 50-56

  Brown, Fred ^a   Benkirane, Nadia ^b   Limal, David ^b   Halimi, Hubert ^b   Newman, John F E ^a   Van Regenmortel, Marc H V ^b   Briand, Jean Paul ^b   Muller, Sylviane ^b  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Foot and mouth disease virus; Neutralization; Synthetic peptide

Indexed keywords

AMINO ACID; CAPSID PROTEIN; EPITOPE; HEMOCYANIN; NEUTRALIZING ANTIBODY; PEPTIDE;

ANTIBODY RESPONSE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOT AND MOUTH DISEASE VIRUS; GUINEA PIG; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; SEROTYPE; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; APHTHOVIRUS; CAPSID; CAPSID PROTEINS; GUINEA PIGS; IMMUNE SERA; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; SEROTYPING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033588523     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00169-3     Document Type: Article

References (28)

1. Acharya R., Fry E., Stuart D., Fox G., Rowlands D., Brown F. The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution. Nature. 337:1989;709-716.
2. Brown F. Antibody recognition and neutralization of foot-and-mouth disease virus. Sem Virol. 6:1995;243-248.
3. Fox G., Parry N.R., Barnett P.V., McGinn B., Rowlands D.J., Brown F. The attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid). J Gen Virol. 70:1989;625-637.
4. Baxt B., Becker Y. The effect of peptides containing the arginine-glycine-aspartic acid sequence on the adsorption of foot-and-mouth disease virus to tissue culture cells. Virus Genes. 4:1990;73-83.
5. Mason P.W., Rieder E., Baxt B. RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathway. Proc Natl Acad Sci USA. 91:1994;1932-1936.
6. Rowlands D.J., Sangar D.V., Brown F. Relationship of the antigenic structure of foot-and-mouth disease virus to the process of infection. J Gen Virol. 13:1971;85-93.
7. Zamorano P., Wigdorowitz A., Pérez-Filgueira M., Carrillo C., Escribano J.M., Sadir A.M., Borca M.V. A 10-amino-acid linear sequence of VP1 of foot-and-mouth disease virus containing B- and T-cell epitopes induces protection in mice. Virology. 212:1995;614-621.
8. Zamorano P.I., Wigdorowitz A., Perez-Filgueira M., Escribano J.M., Sadir A.M., Borca M.V. Induction of anti-foot-and-mouth disease virus T- and B-cell responses in cattle immunized with a peptide representing ten amino acids of VP1. Vaccine. 16:1998;558-563.
9. McKenna T.St.C., Rieder E., Lubroth J., Baxt B.B., Mason P.W. Strategy for producing new foot-and-mouth disease vaccines that display complex epitopes. J Biotech. 44:1996;83-89.
10. Martinez M.A., Verdaguer N., Mateu M.G., Domingo E. Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus. Proc Natl Acad Sci USA. 94:1997;6798-6802.
11. Rowlands D.J., Clarke B.E., Carroll A.R., Brown F., Nicholson B.H., Bittle J.L., Houghten R.A., Lerner R.A. Chemical basis of antigenic variation in foot-and-mouth disease virus. Nature. 306:1983;694-697.
12. Briand J.P., Benkirane N., Guichard G., Newman J.F.E., Van Regenmortel M.H.V., Brown F., Muller S. A retro-inverso peptide corresponding to the GH loop of foot-and-mouth disease virus elicits high levels of long-lasting protective neutralizing antibodies. Proc Natl Acad Sci USA. 94:1997;12545-12550.
13. Meloen R.H., Rowlands D.J., Brown F. Comparison of the antibodies elicited by the individual structural polypeptides of foot-and-mouth disease and polio viruses. J Gen Virol. 45:1979;761-763.
14. Halimi H., Dumortier H., Briand J.P., Muller S. Comparison of two different methods using overlapping synthetic peptides for localizing linear B-cell epitopes in the U1 snRNP-C autoantigen. J Immunol Methods. 199:1996;77-85.
15. Bittle J.L., Houghten R.A., Alexander H., Shinnick T.M., Sutcliffe J.G., Lerner R.A., Rowlands D.J., Brown F. Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature. 298:1982;30-33.
16. Pfaff E., Mussgay M., Bohm H.O., Schulz G.E., Schaller H. Antibodies against a preselected peptide recognize and neutralize foot-and-mouth disease virus. EMBO J. 1:1982;869-874.
17. Strohmaier K., Franze R., Adam K.H. Location and characterization of the antigenic portion of the FMDV immunizing protein. J Gen Virol. 59:1982;295-306.
18. Hernandez J., Luz Valero M., Andreu D., Domingo E., Mateu M.G. Antibody and host cell recognition of foot-and-mouth disease virus (serotype C) cleaved at the Arg-Gly-Asp (RGD) motif: a structural interpretation. J Gen Virol. 77:1996;257-264.
19. Barnett P.N., Pullen L., Staple R.F., Lee L.J., Butcher R., Parkinson D., Doel T.R. A protective antipeptide antibody against the immunodominant site of the A24 Cruzerio strain of foot-and-mouth disease virus and its reactivity with other subtype viruses containing the same minimum binding sequence. J Gen Virol. 77:1996;1011-1018.
20. Francis M.J., Fry C.M., Rowlands D.J., Bittle J.L., Houghten R.A., Lerner R.A., Brown F. Immune response to uncoupled peptides of foot-and-mouth disease virus. Immunology. 61:1987;1-6.
21. Verdaguer N., Mateu M.G., Andreu D., Giralt E., Domingo E., Fita I. Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction. EMBO J. 14:1995;1690-1696.
22. Verdaguer N., Mateu M.G., Bravo J., Domingo E., Fita I. Induced pocket to accommodate the cell attachment Arg-Gly-Asp motif in a neutralizing antibody against foot-and-mouth disease virus. J Mol Biol. 256:1996;364-376.
23. McCullough K.C., De Simone F., Brocchi E., Capucci L., Crowther J.R., Kihm U. Protective immune response against foot-and-mouth disease. J Virol. 66:1992;1835-1840.
24. vβ3 in vitro. J Virol. 71:1996;8357-8361.
25. vβ3 as its receptor. J Virol. 72:1998;3587-3594.
26. vβ3 integrin, the vitronectine receptor. Virology. 203:1994;357-365.
27. vβ3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells. J Virol. 69:1995;2664-2666.
28. Roivainen M., Hyypiä T., Pürainen L., Kalkkinen N., Stanway G., Hovi T. RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases. J Virol. 65:1991;4735-4740.