Covalent or trapped? PFG diffusion MAS NMR for combinatorial chemistry

Tetrahedron Letters

Volumn 40, Issue 34, 1999, Pages 6141-6143

  Shapiro, Michael J ^a   Chin, Jefferson ^a   Chen, Aidi ^a   Wareing, James R ^a   Tang, Qing ^a   Tommasi, Ruben A ^a   Marepalli, Hanumantha R ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COVALENT BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0033588010     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01154-5     Document Type: Article

References (15)

1. (a) Fitch, W. L.; Detre, G.; Holmes, C. P.; Shoolery, J. N.; Keifer, P. A. J. Org. Chem. 1994, 59, 7995-7996.
2. (b) Anderson, R. C.; Jarema, M. A.; Shapiro, M. J.; Stokes, J. P.; Ziliox, M. J. Org. Chem. 1995, 60, 2560-2651.
3. (a) Shapiro, M. J.; Kumaravil, G.; Fetter, R. C.; Beveridge, R. Tetrahedron Lett. 1996, 37, 4671-4674.
4. (b) Anderson, R. C.; Shapiro, M. J.; Stokes, J. P. Tetrahedron Lett. 1995, 36, 5311-5314.
5. (c) Pop, I.; Dhalluin, C.; Depréz, B.; Melnyk, P.; Lippens, G.; Tartar, A. Tetrahedron 1996, 52, 12209-12222.
6. Hahn, E. L. Phys. Rev. 1950, 80, 580.
7. Shapiro, M. J.; Chin, J.; Marti, R. E.; Jarosinski, M. A. Tetrahedron Lett. 1997, 38, 1333.
8. (a) Mass, W. E.; Laukien, F. H.; Cory, D. G. J. Am. Chem. Soc. 1996, 118, 13085-13086.
9. (b) Chin, J. A.; Fell, B.; Pochapsky, S.; Shapiro, M. J.; Wareing, J. R. J. Org. Chem. 1998, 63, 1309-1311.
10. Van Zijl, P. C.; Moonen C. T. J. Magn. Reson. 1990, 87, 18.
11. (a) Lin, M.; Shapiro, M. J.; Wareing, J. R. J. Org. Chem. 1997, 62, 8930.
12. (b) Lin, M.; Shapiro, M. J.; Wareing, J. R. J. Am. Chem. Soc. 1997, 119, 5249-5250.
13. A similar method has been recently applied to remove solvent signals from MAS resin spectra. Warrass, R.; Wieruszeski, J.-M.; Lippens, G. J. Am. Chem. Soc. 1999, 121, 3787-3788.
14. 7 to which benzyol- Phe was added. All 1D NMR data were obtained using the bpp-LED pulse sequence. The gradient strength was about 35 G/cm for 2 ms. The COSY spectrum shown was obtained using pulse sequences described in Ref. 7.
15. Tommasi, R. A.; Nantermet, P. G.; Shapiro, M. J.; Chin, J. Tetrahedron Lett. 1998, 39, 5477.