Mechanical ventilation in a cohort of elderly patients admitted to an intensive care unit

Annals of Internal Medicine

Volumn 131, Issue 2, 1999, Pages 96-104

  Ely, E Wesley ^a   Evans, Gregory W ^b   Haponik, Edward F ^c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; ELDERLY CARE; FEMALE; HEALTH CARE COST; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; OUTCOMES RESEARCH; PRIORITY JOURNAL; RESPIRATORY FAILURE; SCREENING TEST; WEANING;

EID: 0033587660     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-131-2-199907200-00004     Document Type: Article

References (54)

1. Hobbs F, Damon BL, Taeuber CM. Sixty-Five Plus in the United States. Washington, DC: U.S. Department of Commerce, Economics, and Statistics Administration, Bureau of the Census; 1996.
2. Shaw AB. Age as a basis for healthcare rationing. Support for agist policies. Drugs Aging. 1996;9:403-5.
3. Baltussen R, Leidl R, Ament A. The impact of age on cost-effectiveness ratios and its control in decision making. Health Econ. 1996;5:227-39.
4. Sage WM, Hurst CR, Silverman JF, Bortz WM 2d. Intensive care for the elderly: outcome of elective and nonelective admissions. J Am Geriatr Soc. 1987;35:312-8.
5. Singer PA, Lowy FH. Rationing, patient preferences, and cost of care at the end of life. Arch Intern Med. 1992;152:478-80.
6. Giugliano RP, Camargo CA Jr. Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, et al. Elderly patients receive less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med. 1998;158:1113-20.
7. Hamel MB, Philips RS, Teno JM, Lynn J, Galanos AN, Davis RB, et al. Seriously ill hospitalized adults: do we spend less on older patients? SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. J Am Geriatr Soc. 1996;44:1043-8.
8. Hakim RB, Teno JM, Harrell FE Jr, Knaus WA, Wenger N, Phillips RS, et al. Factors associated with do-not-resuscitate orders: patients' preferences, prognoses, and physicians' judgments. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcome and Risks of Treatment. Ann Intern Med. 1996;125:284-93.
9. Teno JM, Hakim RB, Knaus WA, Wenger NS, Phillips RS, Wu AW, et al. Preferences for cardiopulmonary resuscitation: physician-patient agreement and hospital resource use. The SUPPORT Investigators. J Gen Intern Med. 1995;10:179-86.
10. Goldberg AI. Life-sustaining technology and the elderly. Prolonged mechanical ventilation factors influencing the treatment decision. Chest. 1988;94: 1277-82.
11. Knaus WA, Draper EA, Wagner DP, Zimmerman JE, An evaluation of outcome from intensive care in major medical centers. Ann Intern Med. 1986; 104:410-8.
12. Cohen IL, Lambrinos J. Investigating the impact of age on outcome of mechanical ventilation using a population of 41,848 patients from a statewide database. Chest. 1995;107:1673-80.
13. Kurek CJ, Cohen IL, Lambrinos J, Minatoya K, Booth FV, Chalfin DB. Clinical and economic outcome of patients undergoing tracheostomy for prolonged mechanical ventilation in New York state during 1993: analysis of 6,353 cases under diagnosis-related group 483. Crit Care Med. 1997;25: 983-8.
14. Kurek CJ, Dewar D, Lambrinos J, Booth FV, Cohtn IL. Clinical and economic outcome of mechanically ventilated patients in New York State during 1993: analysis of 10,473 cases under DRG 475. Chest. 1998;114:214-22.
15. Nunn JF, Milledge JS, Singaraya J. Survival of patients ventilated in an intensive therapy unit. Br Med J. 1979;1:1525-7.
16. Campion EW, Mulley AG, Goldstein RL, Bamett GO, Thibault GE. Medical intensive care for the elderly. A study of current use, costs, and outcomes. JAMA. 1981;246:2052-6.
17. Fedullo AJ, Swinburne AJ. Relationship of patient age to cost and survival in a medical ICU. Crit Care Med. 1983;11:155-9.
18. Witek TJ Jr, Schachter EN, Dean NL, Beck GJ. Mechanically assisted ventilation in a community hospital. Immediate outcome, hospital charges, and follow-up of patients. Arch Intern Med. 1985;145:235-9.
19. McLean RF, McIntosh JD, Kung GY, Leung DM, Byrick RJ. Outcome of respiratory intensive care for the elderly. Crit Care Med. 1985;13:625-9.
20. Elpern EH, Larson R, Douglass P, Rosen RL, Bone RC. Long-term outcomes for elderly survivors of prolonged ventilator assistance. Chest. 1989; 96:1120-4.
21. Tran DD, Groeneveld AB, van der Meulen J, Nauta JJ, Strack van Schijndel RJ, Thijs LG. Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med. 1990;18:474-9.
22. O'Donnell A, Bohner B. Outcome in patients requiring prolonged mechanical ventilation: three year experience. Chest. 1991;100:295.
23. Pesau B, Falger S, Berger E, Weimann J, Schuster E, Leithner C, et al. Influence of age on outcome of mechanically ventilated patients in an intensive care unit. Crit Care Med. 1992;20:489-92.
24. Gracey DR, Naessens JM, Krishan I, Marsh HM. Hospital and posthospital survival in patients mechanically ventilated for more than 29 days. Chest. 1992;101:211-4.
25. Chelluri L, Pinsky MR, Grenvik AN. Outcome of intensive care of the "oldest-old" critically ill patients. Crit Care Med. 1992;20:757-61.
26. Stauffer JL, Fayter NA, Graves B, Cromb M, Lynch JC, Goebel P. Survival following mechanical ventilation for acute respiratory failure in adult men. Chest. 1993;104:1222-9.
27. Swinburne AJ, Fedullo AJ, Bixby K, Lee DK, Wahl GW. Respiratory failure in the elderly. Analysis of outcome after treatment with mechanical ventilation. Arch Intern Med. 1993;153:1657-62.
28. Cohen IL, Lambrinos J, Fein IA. Mechanical ventilation for the elderly patient in intensive care. Incremental changes and benefits. JAMA. 1993;269:1025-9.
29. Papadakis MA, Lee KK, Browner WS, Kent DL, Matchar DB, Kagawa MK, et al. Prognosis of mechanically ventilated patients. West J Med. 1993; 159:659-64.
30. Dardaine V, Constant T, Lasfargues G, Perrotin D, Ginies G. Outcome of elderly patients requiring ventilatory support in intensive care. Aging (Milano). 1995;7:221-7.
31. Steiner T, Mendoza G, De Georgia M. Schellinger P, Hotle R, Hacke W. Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit. Stroke. 1997;28:711-5.
32. Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1159-64.
33. Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335:1864-9.
34. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818-29.
35. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988;138:720-3.
36. Cox DR. Regression models and life-tables. Journal of the Royal Statistical Society. 1972;34:187-220.
37. Nuckton TJ, List ND. Age as a factor in critical care unit admissions. Arch Intern Med. 1995;155:1087-92.
38. Heuser MD, Case LD, Ettinger WH. Mortality in intensive care patients with respiratory disease. Is age important? Arch Intern Med. 1992;152: 1683-8.
39. Bourt C, Dowd B. McCaffrey D, Boult L, Hernandez R, Krulewitch H. Screening elders for risk of hospital admission. J Am Geriatr Soc. 1993;41: 811-7.
40. Knaus WA, Harrell FE Jr, Lynn J, Goldman L, Phillips RS, Connors AF Jr, et al. The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med. 1995;122:191-203.
41. Knaus WA. Prognosis with mechanical ventilation: the influence of disease, severity of disease, age, and chronic health status on survival from an acute illness. Am Rev Respir Dis. 1989;140(2 Pt 2):S8-13.
42. Knaus WA, Wagner DP, Lynn J. Short-term mortality predictions for critically ill hospitalized adults: science and ethics. Science. 1991;254:389-94.
43. Fried LP, Kronmal RA, Newman AB, Bild DE, Mittelmark MB, Polak JF, et al. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA. 1998;279:585-92.
44. Barrett-Connor E, Stuenkel CA. Questions of life and death in old age [Editorial]. JAMA. 1998;279:622-3.
45. Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998;279:1187-93.
46. Davis RB, lezzoni LI, Phillips RS, Reiley P, Coffman GA, Safran C. Predicting in-hospital mortality. The importance of functional status information. Med Care. 1995;33:906-21.
47. Vita AJ, Terry RB, Hubert HB, Fries JF. Aging, health risks, and cumulative disability. N Engl J Med. 1998;338:1035-41.
48. Campion EW. Aging better [Editorial]. N Engl J Med. 1998;338:1064-6.
49. Kollef MH, O'Brien JD, Silver P. The impact of gender on outcome from mechanical ventilation. Chest. 1997;111:434-41.
50. Yuen EJ, Gonnella JS, Louis DZ, Epstein KR, Howell SL, Markson LE. Severity-adjusted differences in hospital utilization by gender. Am J Med Qual. 1995;10:76-80.
51. Fried TR, Miller MA, Stein MD, Wachtel TJ. The association between age of hospitalized patients and the delivery of advanced cardiac life support. J Gen Intern Med. 1996;11:257-61.
52. Curtis JR, Park DR, Krone MR, Pearlman RA. Use of the medical futility rationale in do-not-attempt-resuscitation orders. JAMA. 1995;273:124-8.
53. Blouin AS, Brent NJ. Downsizing and potential discrimination based on age. J Nurs Admin. 1996;26:3-5.
54. Hamel MB, Teno JM, Goldman L, Lynn J, Davis RB, Galanos AN, et al. Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. Ann Intern Med. 1999;130:116-25.