A comparison of calcium, vitamin D, or both for nutritional rickets in Nigerian children

New England Journal of Medicine

Volumn 341, Issue 8, 1999, Pages 563-568

  Thacher, Tom D ^a   Fischer, Philip R ^b   Pettifor, John M ^c   Lawson, Juliana O ^a   Isichei, Christian O ^a   Reading, James C ^d   Chan, Gary M ^e  

^a UNIVERSITY OF JOS   (Nigeria)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALCITRIOL; CALCIUM; VITAMIN D;

ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM DEFICIENCY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NIGERIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RICKETS; TREATMENT OUTCOME; VITAMIN D DEFICIENCY; WRIST RADIOGRAPHY;

AFRICA; AFRICA SOUTH OF THE SAHARA; AGE FACTORS; BIOLOGY; CALCIUM; CHILD; COMPARATIVE STUDIES; DEFICIENCY DISEASES; DELIVERY OF HEALTH CARE; DEMOGRAPHIC FACTORS; DEVELOPING COUNTRIES; DISEASES; DOUBLE-BLIND STUDIES; ENGLISH SPEAKING AFRICA; FOOD SUPPLEMENTATION; HEALTH; HEALTH SERVICES; METALS; MICRONUTRIENTS; NIGERIA; NUTRITION DISORDERS; NUTRITION PROGRAMS; PHYSIOLOGY; POPULATION; POPULATION CHARACTERISTICS; PRIMARY HEALTH CARE; RESEARCH METHODOLOGY; RESEARCH REPORT; STUDIES; TREATMENT; VITAMINS; WESTERN AFRICA; YOUTH;

ALKALINE PHOSPHATASE; CALCIUM; CALCIUM, DIETARY; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; NIGERIA; RICKETS; VITAMIN D;

EID: 0033584422     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199908193410803     Document Type: Article

References (24)

1. Muhe L, Lulseged S, Mason KE, Simoes EAF. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 1997;349:1801-4.
2. Bhattacharyya AK. Nutritional rickets in the tropics. World Rev Nutr Diet 1992;67:140-97.
3. Zhou H. Rickets in China. In: Glorieux FH, ed. Rickets. Vol. 21 of Nestlé nutrition workshop series. New York: Raven Press, 1991:253-61.
4. Elidrissy A-WTH. Vitamin D-deficiency rickets in Saudi Arabia. In: Glorieux FH, ed. Rickets. Vol. 21 of Nestlé nutrition workshop series. New York: Raven Press, 1991:223-31.
5. Glorieux FH, ed. Rickets. Vol. 21 of Nestle nutrition workshop series. New York: Raven Press, 1991:vii.
6. Okonofua F, Gill DS, Alabi ZO, Thomas M, Bell JL, Dandona P. Rickets in Nigerian children: a consequence of calcium malnutrition. Metabolism 1991;40:209-13.
7. Pettifor JM, Ross P, Wang J, Moodley G, Couper-Smith J. Rickets in children of rural origin in South Africa: is low dietary calcium a factor? J Pediatr 1978;92:320-4.
8. Oginni LM, Worsfold M, Oyelami OA, Sharp CA, Powell DE, Davie MWJ. Etiology of rickets in Nigerian children. J Pediatr 1996;128:692-4.
9. Thacher TD, Ighogboja SI, Fischer PR. Rickets without vitamin D deficiency in Nigerian children. Ambulatory Child Health 1997;3:56-64.
10. Thacher TD, Glew RH, Isichei CO, et al. Rickets in Nigerian children: response to calcium supplementation. J Trop Pediatr 1999;45:202-7.
11. Oginni LM, Sharp CA, Worsfold M, Badru OS, Davie MWJ. Healing of rickets after calcium supplementation. Lancet 1999;353:296-7.
12. Maltz HE, Fish MB, Holliday MA. Calcium deficiency rickets and the renal response to calcium infusion. Pediatrics 1970;46:865-70.
13. Kooh SW, Fraser D, Reilly BJ, Hamilton JR, Gall DG, Bell L. Rickets due to calcium deficiency. N Engl J Med 1977;297:1264-6.
14. Barness LA. Rickets: the chicken or the egg! J Pediatr 1996;129:941-2.
15. Walker ARP. Etiology of nutritional rickets: geographic variations. J Pediatr 1997;130:501-3.
16. Food composition table for use in Africa. In: Agricultural Extension and Research Liaison Services. Soyabeans in the Nigerian diet. Extension bulletin no. 21. Home economics series no. 1. Zaria, Nigeria: Ahmadu Bello University, 1985:62-71.
17. Latham MC. Human nutrition in tropical Africa: a textbook for health workers with special reference to community health problems in East Africa. FAO food and nutrition series no. 11. Rome: Food and Agricultural Organization of the United Nations, 1979:264-76.
18. Gouws E, Langenhoven ML, eds. NRIND food composition tables. 2nd ed. Parow, South Africa: South African Medical Research Council, 1986.
19. Thacher TD, Fischer PR, Pettifor JM, Lawson JO, Manaster BJ, Reading JC. Radiographic scoring method for the assessment of the severity of nutritional rickets. J Trop Pediatr (in press).
20. David L. Common vitamin D-deficiency rickets. In: Glorieux FH, ed. Rickets. Vol. 21 of Nestlé nutrition workshop series. New York: Raven Press, 1991:107-22.
21. Clements MR, Johnson L, Fraser DR. A new mechanism for induced vitamin D deficiency in calcium deprivation. Nature 1987;325:62-5.
22. Thacher TD, Pettifor JM, Fischer PR. "D or not D" - that is the question. J Pediatr 1997;130:332-3.
23. Optimal calcium intake. NIH consensus statement. Vol. 12. No. 4. Bethesda, Md.: NIH Office of Medical Applications of Research, 1994:1-31.
24. Prentice A, Barclay DV. Breast-milk calcium and phosphorus concentrations of mothers in rural Zaire. Eur J Clin Nutr 1991;45:611-7.