The G464S amino acid substitution in Candida albicans sterol 14α-demethylase causes fluconazole resistance in the clinic through reduced affinity

Biochemical and Biophysical Research Communications

Volumn 262, Issue 1, 1999, Pages 174-179

  Kelly, Steven L ^a   Lamb, David C ^a   Loeffler, Juergen ^b   Einsele, Herman ^b   Kelly, Diane E ^a  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ENZYME; ERGOSTEROL; FLUCONAZOLE; HEME; METHYL GROUP; STEROL 14ALPHA DEMETHYLASE; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG RESISTANCE; ENZYME ACTIVITY; FUNGUS MUTATION; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY; STEROL SYNTHESIS;

ANIMALIA; CANDIDA ALBICANS; CORYNEBACTERINEAE; FUNGI;

EID: 0033584392     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1999.1136     Document Type: Article

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