Context generalization in Drosophila visual learning requires the mushroom bodies

Nature

Volumn 400, Issue 6746, 1999, Pages 753-756

  Liu, Li ^a   Wolf, Reinhard ^a   Ernst, Roman ^a   Heisenberg, Martin ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DROSOPHILA MELANOGASTER; LEARNING; MEMORY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SIMULATION; VISUAL SYSTEM;

EID: 0033584335     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/23456     Document Type: Article

References (29)

1. Tarpy, R. M. Contemporary Learning Theory and Research (McGraw-Hill, New York, 1997).
2. Bouton, M. E. Context, time, and memory retrieval in the interference paradigm of Pavlovian learning. Psychol. Bull. 114, 80-99 (1993).
3. Wolf, R. & Heisenberg, M. Basic organization of operant behavior as revealed in Drosophila flight orientation. J. Comp. Physiol. A 169, 699-705 (1991).
4. Heisenberg, M. & Wolf, R. Reafferent control of optomotor yaw torque in Drosophila melanogaster. J. Comp. Physiol. A 163, 373-388 (1988).
5. Heisenberg, M., Borst, A., Wagner, S. & Byers, D. Drosophila mushroom body mutants are deficient in olfactory learning. J. Neurogenet. 2, 1-30 (1985).
6. de Belle, J. S. & Heisenberg, M. Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies. Science 263, 692-695 (1994).
7. Connolly, J. B. et al. Associative learning disrupted by impaired G(S) signalling in Drosophila mushroom bodies. Science 274, 2104-2107 (1996).
8. Wolf, R. et al. Drosophila mushroom bodies are dispensable for visual, tactile, and motor learning. Learn. Mem. 5, 166-178 (1998).
9. Pavlov, I. P. Conditioned Reflexes (trans. Anrep, G. V.) (Oxford Univ. Press, London, 1927).
10. Prokop, A. & Technau, G. M. Normal function of the mushroom body defect gene ot Drosophila is required for the regulation of the number and proliferation of neuroblasts. Dev. Biol. 161, 321-337 (1994).
11. Martin, J.-R., Ernst, R. & Heisenberg, M. Mushroom bodies suppress locomotor activity in Drosophila melanogaster. Learn. Mem. 5, 179-191 (1998).
12. de Belle, J. S. & Heisenberg, M. Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: A case study of the mushroom body miniature gene (mbm). Proc. Natl Acad. Sci. 93, 9875-9880 (1996).
13. Sweeney, S. T., Broadie, K., Keane, J., Niemann, H. & O'Kane, C. J. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron 14, 341-351 (1995).
14. Bickel, W. K. & Etzel, B. C. The quantal nature of controlling stimulus-response relations as measured in tests of stimulus generalization. J. Exp. Anal. Behav. 44, 245-270 (1985).
15. Ernst, R. & Heisenberg, M. The memory template in Drosophila pattern vision at the flight simulator. Vis. Res. (in the press).
16. Tuly, T. & Quinn, W. G. Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. A 157, 263-277 (1985).
17. Heisenberg, M. & Wolf, R. in Studies of Brain Function Vol. XII (ed. Braitenberg, V.) (Springer, Berlin, 1984).
18. Rybak, J. & Menzel, R. Integrative properties of the Pel neuron, a unique mushroom body output neuron. Learn. Mem. 5, 133-145 (1998).
19. Li, Y.-S. & Strausfeld, N. J. Morphology and sensory modality of mushroom body efferent neurons in the brain of the cockroach, Periplaneta americana. J. Comp. Neurol. 387, 631-650 (1997).
20. Schildberger, K. Multimodal interneurons in the cricket brain: properties of identified extrinsic mushroom body cells. J. Comp. Physiol. A 154, 71-79 (1984).
21. Schürmann, F. Bemerkungen zur Funktion der Corpora pedunculata im Gehirn der Insekten aus morphologischer Sicht. Exp. Brain Res. 19, 406-432 (1974).
22. Erbre, J., Homberg, U. & Gronenberg, W. in Anthropod Brain: Its Evolution, Development, Structure and Function (ed. Gupta, P.) (Wiley, New York, 1987).
23. Strausfeld, N. J., Hansen, L., Li, Y., Gomez, R. S. & Ito, K. Evolution, discovery, and interpretations of arthropod mushroom bodies. Learn. Mem. 5, 11-37 (1998).
24. Ito, K. et al. The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen. Learn. Mem. 5, 52-77 (1998).
25. Barth, M. & Heisenberg, M. Vision affects mushroom bodies and central complex in Drosophila melanogaster. Learn. Mem. 4, 219-229 (1997).
26. Guo, A. et al. Conditioned visual flight orientation in Drosophila: Dependence on age, practice and diet. Learn. Mem. 3, 49-59 (1996).
27. Ashburner, M. Drosophila. A Laboratory Manual. Protocoll 112. 254 (Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY, 1989).
28. Buchner, E. et al. Cell-specific immuno-probes for the brain of normal and mutant Drosophila melanogaster. I. Wild type visual system. Cell Tissue Res. 253, 357-370 (1988).
29. Crittenden, J. R., Skoulakis, E. M. C., Han, K.-A., Kalderon, D. & Davis, R. L. tripartite mushroom body architecture revealed by antigenic markers. Learn. Mem. 5, 38-51 (1998).