Roaming through methodology. XIV. Premature stopping of a randomized trial;Dwalingen in de methodologie. XIV. Het voortijdig beeindigen van een gerandomiseerde trial

Nederlands Tijdschrift voor Geneeskunde

Volumn 143, Issue 25, 1999, Pages 1305-1308

  Vandenbroucke, J P ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

ARTICLE; CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MONITORING; DRUG RESEARCH; DRUG SAFETY; EXPERIMENT; HUMAN; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL;

BIAS (EPIDEMIOLOGY); DATA INTERPRETATION, STATISTICAL; ETHICS, MEDICAL; HUMAN EXPERIMENTATION; HUMANS; NETHERLANDS; PROFESSIONAL STAFF COMMITTEES; RANDOMIZED CONTROLLED TRIALS; RESEARCH; RESEARCH DESIGN;

EID: 0033584030     PISSN: 00282162     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

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2. Pocock SJ, While I. Trials stopped early: too good to be true? Lancet 1999;353:943-4.
3. Lau WY, Leung TWT, Ho SKW, Chan M, Machin D, Lau J, et al. Adjuvant intra-arterial iodine-131 -labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial. Lancet 1999;353:797-801.
4. Sixty Plus Reinfarction Study Research Group. A double-blind trial to assess long-term anticoagulant therapy in elderly patients after myocardial infarction. Lancet 1980;ii:989-94.
5. Wolde S ten, Breedveld FC, Hermans J, Vandenbroucke JP, Laar MA van de, Markusse HM, et al. Randomised placebo-controlled study of stopping second-line drugs in rheumatoid arthritis. Lancet 1996;347:347-52.
6. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, et al. Design and analysis of randomised controlled trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer 1986;34:585-612.