Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1209-1214

  Ganguly, Ashit K ^a   McCormick, Jinping L ^a   Saksena, Anil K ^a   Das, Pradip R ^a   Chan, Tze Ming ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; EVERNIMICIN; EVERNINOMICIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; ENTEROCOCCUS; MINIMUM INHIBITORY CONCENTRATION; STAPHYLOCOCCUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ENTEROCOCCUS; STAPHYLOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ENTEROCOCCUS; STAPHYLOCOCCUS;

EID: 0033583541     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00163-8     Document Type: Article

References (13)

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6. Orthosomycins are a family of oligosaccharide antibiotics which contain one or more orthoester linkages. For a review on orthosomycins, see Wright, D. E. Tetrahedron 1979, 35, 1207
7. Ganguly, A. K.; Sarre, O. Z.; McPhail, A. T.; Miller, R. J.Chem. Soc. Chem. Com. 1979, 22.
8. Ganguly, A. K.; McCormick, J. L.; Chan, T.-M.; Saksena, A. K.; Das, P. R. Tetrahedron Lett. 1997, 38, 7989.
9. Ganguly, A. K.; Girijavallabhan, V. M., Miller, G. H., Sarre, O. Z. J. Antibiotics 1982, 35, 561.
10. See Kocienski, P.J. in "Protecting Groups" Georg Thieme Verlag, New York, 1994, pp 61-68.
11. 13CNMR.
12. b) Chan, T.-M.; Osterman, R. M.; Morton, J. B.; Ganguly, A. K. Magn. Res. Chem. 1997, 35(8), 529.
13. 2 to afford N-Cbz protected 21 (62.2 mg, 55 %) as a white solid which was hydrogenated over 10%Pd/C (15 mg) in EtOH to give 21 (32 mg, 58%).