Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1093-1096

  Tatsu, Yoshiro ^a   Shigeri, Yasushi ^a   Ishida, Atsuhiko ^b   Kameshita, Isamu ^b   Fujisawa, Hitoshi ^b   Yumoto, Noboru ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Enzyme inhibitors; Peptides and polypeptides

Indexed keywords

CALCINEURIN;

ARTICLE; CHEMICAL MODIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PEPTIDE SYNTHESIS; SYNTHESIS; ULTRAVIOLET IRRADIATION;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; LYSINE; NITROBENZENES; PEPTIDE BIOSYNTHESIS;

EID: 0033583492     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00140-7     Document Type: Article

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7. 2-Nitrobenzylalcohol was refluxed with 2 equivalents of phosgene-dimer in THF for 2 h and the solvent and excess reagent were evaporated to give the chloroformate. It was used without purification.
8. 2O) δ =8.11(1H, d, J = 8Hz), 7.75(1H, t, J = 8Hz), 7.61 (1H, d, J = 8Hz), 7.57 (1H, t, J = 8Hz), 5.42 (2H, s), 4.09 (1H, t, J = 6Hz), 3.15 (2H. t, J = 6Hz), 2.00 (1H, m), 1.94 (1H, m), 1.56 (2H, m), 1.46 (2H, m).
9. +] m/z 548.1997.
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