Synthesis of azapeptides from hindered amines leading to novel growth hormone secretagogues

Tetrahedron Letters

Volumn 40, Issue 51, 1999, Pages 9119-9120

  Hansen, Thomas Kruse ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AZAPEPTIDE; GROWTH HORMONE DERIVATIVE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; CHEMICAL REACTION; DRUG SYNTHESIS; HORMONE STRUCTURE; HYPOPHYSIS CELL; NONHUMAN; RAT; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 0033579643     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01888-2     Document Type: Article

References (10)

1. For leading references to this area consult: (a) Bowers, C.Y.; Momany, F.A.; Reynolds, G. A.; Hong, A. Endocrinology 1984, 114, 1531.
2. (b) Schoen, W. R.; Pisano, J. M; Prendergast, K.; Wyvratt, M. J.; Fisher, M. H.: Cheng, K.; Chan, W. W. S.; Butler B.; Smith, R. G.; Ball, R. G. J. Med. Chem. 1994, 37, 897-906.
3. (c) F. A. Momany. C. Y. Bowers, "Growth Hormone Secretagogues". Eds. B. B. Bereu and R. F. Walker, Springer-Verlag, New York, 1996.
4. (d) De Vita, R. J.; Wyvatt, M. J. Drugs of The Future, 1996, 21. 273.
5. (e) Strobl. J. S:; Thomas, M. J. Human growth hormone. Pharmacological Reviews 1994, 46. 1-34.
6. (f) Mayo, K.E. Molecular Endocrinology 1992, 6(10): 1734-1744,
7. (g) Hansen, T.K.; Ankersen, M.; Hansen, B.; Raun, K.; Nielsen, K. K.; Lau: J. Peschke B.; Lundt. B.; Thøgersen H.; Johansen, N. L.; Madsen. K.; Andersen; P. H. J. Med Chem. 1998, 41, 3705-14
8. Gante, J.,Synthesis, 1989, 405-413
9. Han, H.; Janda, K. D. J. Am. Chem. Soc. 1996, 118, 2539-44
10. For proline as an exception see Andre, F.; Marraud, M.; Boussard, G. Tetrahedron. Lett. 1996, 37, 183-186.