Metallopeptide approach to the design of biologically active ligands: Design of specific human neutrophil elastase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1469-1474

  Shi, Yiqun ^a   Sharma, Shubh ^a  

^a Palatin Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LEUKOCYTE ELASTASE; METALLOPROTEINS; PEPTIDES;

EID: 0033577689     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00217-6     Document Type: Article

References (17)

1. (a) Gante, J. Synthesis 1989, 405.
2. (b) Giannis, A.; Kolter, T. Angew. Chem. Int. Engl. 1993, 32, 1244, and references therein.
3. Stein, R. L.; Strimpler, A. M. Biochemistry 1987, 26, 2611.
4. (b) Kettner, C. A.; Shenvi, A. B. J. Biol. Chem. 1984, 259, 15106.
5. (c) Imperiali, B.; Abeles, R. H. Biochemistry 1986, 25, 3760.
6. Johnson, N.P.; Lock, C.J.L.; Wilkinson, G. Inorg. Syntheses. 1967, Vol. IX, 145.
7. Edwards, P.; Bernstein, P. R. Med. Res. Rev. 1994, 14(2), 127.
8. Pulmonary Emphysema and Proteolysis: 1986, Taylor, J. C., Mittman, C., Eds, Academic: NY, 1987; pp1-550.
9. (a) Myers, K. C.; Lewandoski, J. R.; Zimmerman, J. J.; Nunley, D.; Calhoun, W. J. and Dopico, G. A. Am. Rev. Respir. Dis. 1991, 144, 580.
10. (b) Nadel, J. A. Am. Rev. Respir. Dis. 1991, 144, S48.
11. Janoff, A. In Neutral Proteases of Human Polymorphonuclear Leukocytes; Haveerman, K., Janoff, A., Eds.; Urban and Schwarzenberg: Baltimore, 1978; pp 30-417.
12. Janoff, A. Annu. Rev. Med. 1985, 36, 207.
13. (a) Segel, I. H. Enzyme Kinetics; John Wiley and Sons: New York, 1975.
14. (b) Morrison, J. F.; Walsh, C. T. m Advances in Enzymology, Meister, A., Ed.; Wiley: New York, 1988; Vol. 61, pp 201-301.
15. Fehrentz, J.; Castro, B. Synthesis 1983, 676.
16. (a) Bourdillon, M. C.; Hornebeck, W.; Soleilhac, J. M.; Robert, L. Biochem. Soc. Trans. 1984, 12, 876.
17. (b) Hornebeck, W.; Moczar, E.; Szecsi, J.; Robert, L. Biochem. Pharmacol. 1985, 34, 3315.