Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 25, 1999, Pages 5212-5223

  Rosini, Michela ^a   Budriesi, Roberta ^a   Bixel, M Gabriele ^b   Bolognesi, Maria L ^a   Chiarini, Alberto ^a   Hucho, Ferdinand ^b   Krogsgaard Larsen, Povl ^c   Mellor, Ian R ^d   Minarini, Anna ^a   Tumiatti, Vincenzo ^a   Usherwood, Peter N R ^d   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHOCTRAMINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PHILANTHOTOXIN 343; POLYAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FROG; GUINEA PIG; NONHUMAN; POLYAMINE SYNTHESIS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANURA; DIAMINES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ELECTRIC STIMULATION; GUINEA PIGS; HEART ATRIA; MAGNETIC RESONANCE SPECTROSCOPY; MUSCLE, SKELETAL; NICOTINIC ANTAGONISTS; PHOTOAFFINITY LABELS; POLYAMINES; RECEPTORS, MUSCARINIC;

EID: 0033576672     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991110n     Document Type: Article

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