Selective Epimerization of Rapamycin via a Retroaldol/Aldol Mechanism Mediated by Titanium Tetraisopropoxide

Organic Letters

Volumn 1, Issue 12, 1999, Pages 2033-2035

  Yanq, Wu ^a   Digits, Cheryl A ^a   Hatada, Marcos ^a   Narula, Surinder ^a   Rozamus, Leonard W ^a   Huestis, Cameran M ^a   Wong, Jason ^a   Dalgarno, David ^a   Holt, Dennis A ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TITANIUM; TITANIUM ISOPROPOXIDE;

ARTICLE; CATALYSIS; CHEMISTRY; STEREOISOMERISM;

ANTI-BACTERIAL AGENTS; CATALYSIS; IMMUNOSUPPRESSIVE AGENTS; SIROLIMUS; STEREOISOMERISM; TITANIUM;

EID: 0033576435     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol991209o     Document Type: Article

References (16)

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7. 4 similarly and more rapidly yields its oxepane tautomer which reverts to pyran during chromatography (Wu Yang, unpublished). Hughes has reported the preparation and isolation of the oxepane tautomer of rapamycin: Hughes, P.; Musser, J.; Conklin, M.; Russo, R. Tetrahedron Lett. 1992, 33, 4739-4742. (Matrix Presented)
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