Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 16, 1999, Pages 2397-2402

  Nakanishi, Isao ^a   Kinoshita, Takayoshi ^a   Tada, Toshiji ^b,d   Fujita, Takashi ^c   Hatanaka, Hiroshi ^c   Sato, Akihiro ^a  

^a Basic Research Laboratories   (Japan)

^b Analytical Research Laboratories   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d Osaka Prefecture University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FR 901277; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; HUMAN; HYDROPHOBICITY; LIPOPHILICITY; SIMULATION; X RAY ANALYSIS;

AMIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING;

EID: 0033575712     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00408-4     Document Type: Article

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14. Crystallographic data (excluding structure factors) for the structure in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC 124113. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: +44 1223 336033 or e-mail: deposit@ccdc.cam.ac.uk).