Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 16, 1999, Pages 2391-2396

  Frenette, Richard ^a   Hutchinson, John H ^b   Léger, Serge ^a   Thérien, Michel ^a   Brideau, Christine ^a   Chan, Chi C ^a   Charleson, Stella ^a   Ethier, Diane ^a   Guay, Jocelyne ^a   Jones, Tom R ^a   McAuliffe, Malia ^a   Piechuta, Hanna ^a   Riendeau, Denis ^a   Tagari, Philip ^a   Girard, Yves ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (4 CHLOROBENZYL) 3 (TERT BUTYLTHIO) 5 (PYRIDIN 2 YLMETHOXY)INDOL 2 YL] 2,2 DIMETHYLPROPANOIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CALCIMYCIN; INDOLE DERIVATIVE; L 691831; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LIGAND; LIPOXYGENASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SYNTHESIS; DYSPNEA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLEURISY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARRIER PROTEINS; DOGS; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MEMBRANE PROTEINS; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033575681     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00399-6     Document Type: Article

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