In the ventremedial nucleus of the rat hypothalamus, GABA-immunolabeled neurons are abundant and are innervated by both enkephalin- and GABA- immunolabeled axon terminals

Brain Research

Volumn 816, Issue 1, 1999, Pages 58-67

  Commons, Kathryn G ^a   Kow, Lee Ming ^a   Milner, Teresa A ^b   Pfaff, Donald W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Estrogen; Feeding; GAD; Glucose; Lordosis; Opiate; Ultrastructure

Indexed keywords

4 AMINOBUTYRIC ACID; ENKEPHALIN; GLUCOSE;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELL ULTRASTRUCTURE; DENDRITE; FEEDING BEHAVIOR; GABAERGIC TRANSMISSION; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOHISTOCHEMISTRY; INTERNEURON; LORDOSIS; MALE; NERVE ENDING; NERVE PROJECTION; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; RAT; SYNAPSE; ANIMAL; ELECTRON MICROSCOPY; METABOLISM; NERVE CELL; NERVE FIBER; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; AXONS; DENDRITES; ENKEPHALINS; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; MICROSCOPY, ELECTRON; NEURONS; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 0033573583     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01084-1     Document Type: Article

References (42)

1. Beart P.M., Nicolopoulos L.S., West D.C., Headley P.M. An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence. Neuroscience Letters. 85:1988;205-211.
2. Beverly J.L., Beverly M.F., Meguid M.M. Alterations in extracellular GABA in the ventral hypothalamus of rats in response to acute glucoprivation. American Journal of Physiology. 269:1995;1-2.
3. Beverly J.L., Martin R.J. Increased GABA shunt activity in VMN of three hyperphagic rat models. American Journal of Physiology. 256:1989;1-2.
4. Beverly J.L., Martin R.J. Effect of glucoprivation on glutamate decarboxylase activity in the ventromedial nucleus. Physiology and Behavior. 49:1991;295-299.
5. Commons K.G., Milner T.A. Ultrastructural heterogeneity of enkephalin-containing terminals in the rat hippocampal formation. Journal of Comparative Neurology. 358:1995;324-342.
6. Commons K.G., Milner T.A. Ultrastructural relationships between leu-enkephalin- and GABA-containing neurons differ within the hippocampal formation. Brain Research. 724:1996;1-15.
7. Coscina D.V., Nobrega J.N. Anorectic potency of inhibiting GABA transaminase in brain: studies of hypothalamic, dietary and genetic obesities. International Journal of Obesity. 1:1984;191-200.
8. Edelhoff S., Grubin C.E., Karlsen A.E., Adlern D.A., Foster D., Disteche C.M., Lernmark A. Mapping of glutamic acid decarboxylase (GAD) genes. Genomics. 17:1993;93-97.
9. Fahrbach S.E., Morrell J.I., Pfaff D.W. Studies of ventromedial hypothalamic afferents in the rat using three methods of HRP application. Experimental Brain Research. 77:1989;221-233.
10. Fallon J.H., Leslie F.M. Distribution of dynorphin and enkephalin peptides in the rat brain. Journal of Comparative Neurology. 249:1986;293-336.
11. Feldblum S., Erlander M.G., Tobin A.J. Different distributions of GAD-65 and GAD-67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles. Journal of Neuroscience Research. 34:1993;689-706.
12. Fernandez-Guasti A., Larsson K., Beyer C. Lordosis behavior and GABAergic neurotransmission. Pharmacology Biochemistry and Behavior. 24:1986;673-676.
13. Gosnell B.A. Central structures involved in opioid-induced feeding. Federation Proceedings. 46:1987;163-167.
14. Gosnell B.A., Morley J.E., Levine A.S. Opioid-induced feeding: localization of sensitive brain sites. Brain Research. 369:1986;177-184.
15. Grandison L., Guidotti A. Stimulation of food intake by muscimol and beta endorphin. Neuropharmacology. 16:1977;533-536.
16. Grossman B.M., Devore M.L., Kelso E.W., Martin R.J. Effect of glucose and 2-deoxyglucose on hypothalamic GABA release in lactating rats. Physiology and Behavior. 61:1997;169-173.
17. Harlan R.E., Shivers B.D., Romano G.J., Howells R.D., Pfaff D.W. Localization of preproenkephalin mRNA in the rat brain and spinal cord by in situ hybridization. Journal of Comparative Neurology. 258:1987;159-184.
18. Kelly J., Alheid G.F., Newberg A., Grossman S.P. GABA stimulation and blockade in the hypothalamus and midbrain: effects on feeding and locomotor activity. Pharmacology, Biochemistry and Behavior. 7:1977;537-541.
19. Kimura H., Kuriyama K. Distribution of γ-aminobutyric acid (GABA) in the rat hypothalamus: functional correlates of GABA with activities of appetite controlling mechanisms. Journal of Neurochemistry. 24:1975;903-907.
20. Lauber A.H., Romano G.J., Mobbs C.V., Howells R.D., Pfaff D.W. Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat. Brain Research, Molecular Brain Research. 8:1990;47-54.
21. Lauder J.M., Han V.K., Henderson P., Verdoorn T., Towle A.C. Prenatal ontogeny of the GABAergic system in the rat brain: an immunocytochemical study. Neuroscience. 19:1986;465-493.
22. Kamatchi L.G., Veeraragavan K., Chandra D., Bapna J.S. Antagonism of acute feeding response to 2-deoxyglucose and 5-thioglucose by GABA antagonists: the relative role of ventromedial and lateral hypothalamus. Pharmacology, Biochemistry and Behavior. 25:1986;59-62.
23. Masco D., Weigel R., Carrer H.F. γ-Aminobutyric acid mediates ventromedial hypothalamic mechanism controlling the execution of lordotic responses in the female rat. Behavioral Brain Research. 19:1986;153-162.
24. McCarthy M.M., Kaufman L.C., Brooks P.J., Pfaff D.W., Schwartz-Giblin S. Estrogen modulation of mRNA levels for the two forms of glutamic acid decarboxylase (GAD) in female rat brain. Journal of Comparative Neurology. 360:1995;685-697.
25. McCarthy M.M., Malik K.F., Feder H.H. Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area. Brain Research. 507:1990;40-44.
26. McCarthy M.M., Masters D.B., Fiber J.M., Lopez-Colome A.M., Beyer C., Komisaruk B.R., Feder H.H. GABAergic control of receptivity in the female rat. Neuroendocrinology. 53:1991;473-479.
27. McCarthy M.M., Pfaff D.W., Schwartz-Giblin S. Midbrain central gray GABAA receptor activation enhances, and blockade reduces, sexual behavior in the female rat. Experimental Brain Research. 86:1991;108-116.
28. Milner T.A., Bacon C.E. GABAergic neurons in the rat hippocampal formation: ultrastructure and synaptic relationships with catecholaminergic terminals. Journal of Neuroscience. 9:1989;3410-3427.
29. Minano F.J., Meneres Sancho M.S., Sancibrian M., Salinas P., Myers R.D. GABAA receptors in the amygdala: role in feeding in fasted and satiated rats. Brain Research. 586-591:1992;104-110.
30. Morley J.E., Levine A.S., Gosnell B.A., Billington C.J. Neuropeptides and appetite: contribution of neuropharmacological modeling. Federation Proceedings. 43:1984;2903-2907.
31. Nathan B., Bao J., Hsu C.-C., Aguilar P., Wu R., Yarom M., Kuo C.-Y., Wu J.-Y. A membrane form of brain L-glutamate decarboxylase: identification, isolation, and its relation to insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. 91:1994;242-246.
32. Ottersen O.P., Storm-Mathisen J. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique. Journal of Comparative Neurology. 229:1984;374-392.
33. A. Peters, S. Palay, H. Webster, The Fine Structre of the Nervous System, 3rd edn., Oxford University Press, 1991.
34. Romano G.J., Harlan R.E., Shivers B.D., Howells R.D., Pfaff D.W. Estrogen increases proenkephalin messenger ribonucleic acid levels in the ventromedial hypothalamus of the rat. Molecular Endocrinology. 2:1988;1320-1328.
35. Specter S.E., Horwitz B.A., Beverly J.L. Basal and glucoprivic-induced changes in extracellular GABA in the ventral hypothalamus of Zucker rats. American Journal of Physiology. 271:1996;1-2.
36. Tappaz M.L., Brownstein M.J. Origin of glutamate-decarboxylase (GAD)-containing cells in discrete hypothalamic nuclei. Brain Research. 132:1977;95-106.
37. Tappaz M.L., Brownstein M.J., Kopin I.J. Glutamate decarboxylase (GAD) and γ-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigra. Brain Research. 125:1977;109-121.
38. Tappaz M.L., Brownstein M.J., Palkovits M. Distribution of glutamate decarboxylase in discrete brain nuclei. Brain Research. 108:1976;371-379.
39. Tepperman F.S., Hirst M. Effect of intrahypothalamic injection of [D-Ala2,D-Leu5]enkephalin on feeding and temperature in the rat. European Journal of Pharmacology. 96:1983;243-249.
40. Wallis C.J., Luttge W.G. Influence of estrogen and progesterone on glutamic acid decarboxylase activity in discrete regions of rat brain. Journal of Neurochemistry. 34:1980;609-613.
41. Woods J.S., Leibowitz S.F. Hypothalamic sites sensitive to morphine and naloxone: effects on feeding behavior. Pharmacology, Biochemistry and Behavior. 23:1985;431-438.
42. Zieglgansberger W., French E., Siggins G., Bloom F. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science. 205:1979;415-417.