Generation and characterization of hammerhead ribozymes targeting rodent metallothionein-I and -II ribonucleic acid

Toxicology and Applied Pharmacology

Volumn 161, Issue 3, 1999, Pages 294-301

  Lee, Kai Fai ^a   Lau, Kin Mang ^a   Ho, Shuk Mei ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METALLOTHIONEIN; RIBOZYME;

ARTICLE; CELL IMMORTALIZATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; EXPRESSION VECTOR; MOUSE; NONHUMAN; PROSTATE EPITHELIUM; PROTEIN DEGRADATION; PROTEIN TARGETING; RAT;

RODENTIA;

EID: 0033572640     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8821     Document Type: Article

References (30)

1. Amarzguioui M., Prydz H. Hammerhead ribozyme design and application. Cell Mol. Life Sci. 54:1998;1175-1202.
2. Arora V., Iversen P. L., Ebadi M. Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides. Biochem. Biophys. Res. Commun. 246:1998;711-718.
3. Bataineh Z. M., Heidger P. M. Jr., Thompson S. A., Timms B. G. Immunocytochemical localization of metallothionein in the rat prostate gland. Prostate. 9:1986;397-410.
4. Beattie R. M., Camacho-Hubner C., Wacharasindhu S., Cotterill A. M., Walker-Smith J. A., Savage M. O. Responsiveness of IGF-I and IGFBP-3 to therapeutic intervention in children and adolescents with Crohn's disease. Clin. Endocrinol. 49:1998;483-489.
5. Beck J., Nassal M. A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal. Nucleic Acids Res. 23:1995;4954-4962.
6. Birikh K. R., Heaton P. A., Eckstein F. The structure, function and application of the hammerhead ribozyme. Eur. J. Biochem. 245:1997;1-16.
7. Chang S. M., Chung L. W. Interaction between prostatic fibroblast and epithelial cells in culture: Role of androgen. Endocrinology. 125:1989;2719-2727.
8. Coogan T. P., Shiraishi N., Waalkes M. P. Apparent quiescence of the metallothionein gene in the rat ventral prostate: Association with cadmium-induced prostate tumors in rats. Environ. Health Perspect. 102:1994;137-139.
9. Du Z., Ricordi C., Podack E., Pastori R. L. A hammerhead ribozyme that cleaves perforin and fas-ligand RNAs in vitro. Biochem. Biophys. Res. Commun. 226:1996;595-600.
10. Durnam D. M., Perrin F., Gannon F., Palmiter R. D. Isolation and characterization of the mouse metallothionein-I gene. Proc. Natl. Acad. Sci. USA. 77:1980;6511-6515.
11. Fischer E. H., Davie E. W. Recent excitement regarding metallothionein. Proc. Natl. Acad. Sci. USA. 95:1998;3333-3334.
12. Foster R., Gedamu L. Functional analyses of promoter elements responsible for the differential expression of the human metallothionein (MT)-IG and MT-IF genes. J. Biol. Chem. 266:1991;9866-9875.
13. Ghatak S., Oliveria P., Kaplan P., Ho S. M. Expression and regulation of metallothionein mRNA levels in the prostates of noble rats: Lack of expression in the ventral prostate and regulation by sex hormones in the dorsolateral prostate. Prostate. 29:1996;91-100.
14. Heidenreich O., Eckstein F. Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1. J. Biol. Chem. 267:1992;1904-1909.
15. Herschlag D. Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: More isn't always better. Proc. Natl. Acad. Sci. USA. 88:1991;6921-6925.
16. James W., Cowe E. Computational approaches to the identification of ribozyme target sites. Methods Mol. Biol. 74:1997;17-26.
17. Lee K. F., Lau K. M., Ho S. M. Effects of cadmium on metallothionein-I and metallothionein-II mRNA expression in rat ventral, lateral, and dorsal prostatic lobes: Quantification by competitive RT-PCR. Toxicol. Appl. Pharmacol. 154:1999;20-27.
18. Lieber A., Strauss M. Selection of efficient cleavage sites in target RNAs by using a ribozyme expression library. Mol. Cell Biol. 15:1995;540-551.
19. Maret W., Vallee B. L. Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc. Natl. Acad. Sci. USA. 95:1998;3478-3482.
20. Masters B. A., Kelly E. J., Quaife C. J., Brinster R. L., Palmiter R. D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA. 91:1994;584-588.
21. Ruffner D. E., Stormo G. D., Uhlenbeck O. C. Sequence requirements of the hammerhead RNA self-cleavage reaction. Biochemistry. 29:1990;10695-10702.
22. Scott W. G., Klug A. Ribozymes: Structure and mechanism in RNA catalysis. Trends Biochem. Sci. 21:1996;220-224.
23. Shimayama T., Nishikawa S., Taira K. Generality of the NUX rule: Kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of hammerhead ribozymes. Biochemistry. 34:1995;3649-3654.
24. Suzuki T., Yamanaka H., Tamura Y., Nakajima K., Kanatani K., Kimura M., Otaki N. Metallothionein of prostatic tissues and fluids in rats and humans. Tohoku J. Exp. Med. 166:1992;251-257.
25. Takeda A., Hisada H., Okada S., Mata J. E., Ebadi M., Iversen P. L. Tumor cell growth is inhibited by suppressing metallothionein-I synthesis. Cancer Lett. 116:1997;145-149.
26. Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7:1991;337-347.
27. Umeyama T., Saruki K., Imai K., Yamanaka H., Suzuki K., Ikei N., Kodaira T., Nakajima K., Saitoh H., Kimura M. Immunohistochemical demonstration of metallothionein in the rat prostate. Prostate. 10:1987;257-264.
28. Werner M., Uhlenbeck O. C. The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res. 23:1995;2092-2096.
29. Xie Y., Chen X., Wagner T. E. A ribozyme-mediated, gene "knockdown" strategy for the identification of gene function in zebrafish. Proc. Natl. Acad. Sci. USA. 94:1997;13777-13781.
30. Zoumadakis M., Tabler M. Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes. Nucleic Acids Res. 23:1995;1192-1196.