Cell type-specific activation of neuronal nicotinic acetylcholine receptor subunit genes by Sox10

Journal of Neuroscience

Volumn 19, Issue 22, 1999, Pages 9747-9755

  Liu, Qun ^a   Melnikova, Irena N ^a   Hu, Minjie ^a,b   Gardner, Paul D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Ligand gated ion channel; nACh receptor; POU; Sox10; Transcriptional regulation

Indexed keywords

CHOLINERGIC RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CHANNEL GATING; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NEURAL CREST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; RAT; TRANSCRIPTION REGULATION;

EID: 0033571937     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-22-09747.1999     Document Type: Article

References (53)

1. Ambrosetti D-C, Basilico C, Dailey L (1997) Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol Cell Biol 17:6321-6329.
2. Bigger CB, Casanova EA, Gardner PD (1996) Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes: functional interactions between Sp1 and the rat β4 subunit gene promoter. J Biol Chem 271:32842-32848.
3. Bigger CB, Melnikova IN, Gardner PD (1997) Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor β4 subunit gene. J Biol Chem 272:25976-25982.
4. Bondurand N, Kobetz A, Pingault V, Lemort N, Encha-Razavi F, Couly G, Goerich DE, Wegner M, Abitbol M, Goossens M (1998) Expression of the SOX10 gene during human development. FEBS Lett 432:168-172.
5. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jensen A, Gardner PD, Ballivet M, Deneris ES, McKinnon D, Heinemann S, Patrick J (1990) α3, α5, β4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem 265:4472-4482.
6. Boyd RT (1994) Sequencing and promoter analysis of the genomic region between the rat neuronal nicotinic acetylcholine receptor β4 and α3 genes. J Neurobiol 25:960-973.
7. Boyd RT (1997) The molecular biology of neuronal nicotinic acetylcholine receptors. Crit Rev Toxicol 27:299-318.
8. Campos-Caro A, Carrasco-Serrano C, Valor LM, Viniegra S, Ballesta JJ, Criado M (1999) Multiple functional Sp1 domains in the minimal promoter region of the neuronal nicotinic receptor α5 subunit gene. J Biol Chem 274:4693-4701.
9. Conroy WG, Berg DK (1995) Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit combinations. J Biol Chem 270:4424-4431.
10. Conroy WG, Vernallis AB, Berg DK (1993) The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron 9:679-691.
11. Daubas P, Klarsfeld A, Garner I, Pinset C, Cox R, Buckingham M (1988) Functional activity of the two promoters of the myosin alkali light chain gene in primary muscle cell cultures: comparison with other muscle gene promoters and other culture systems. Nucleic Acids Res 16:1251-1270.
12. Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (1992) A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res 20:2887.
13. Du Q, Tomkinson AE, Gardner PD (1997) Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes: a possible role for the DNA-binding protein Pura. J Biol Chem 272:14990-14995.
14. Du Q, Melnikova IN, Gardner PD (1998) Differential effects of hnRNP K on Sp1- and Sp3-mediated transcriptional activation of a neuronal nicotinic acetylcholine receptor promoter. J Biol Chem 273:19877-19883.
15. Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, Heinemann S (1994) α9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705-715.
16. Fornasari D, Battaglioli E, Flora A, Terzano S, Clementi F (1997) Structural and functional characterization of the human α3 nicotinic subunit gene promoter. Mol Pharmacol 51:250-261.
17. Fyodorov D, Deneris E (1996) The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter. Mol Cell Biol 16:5004-5014.
18. Fyodorov D, Nelson T, Deneris E (1998) Pet-1, a novel ETS domain factor that can activate neuronal nAChR gene transcription. J Neurobiol 34:151-163.
19. Gerzanich V, Kuryatov A, Anand R, Lindstrom J (1997) "Orphan" α6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor. Mol Pharmacol 51:320-327.
20. Gey GO, Coffman WD, Kubicek MT (1952) Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res 12:264-265.
21. Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
22. Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Münsterberg A, Vivian N, Goodfellow P, Lovell-Badge R (1990) A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346:245-250.
23. Hammond DN, Lee HJ, Tonsgard JH, Wainer BH (1990) Development and Characterization of clonal cell lines derived from septal cholinergic neurons. Brain Res 512:190-200.
24. Herbarth B, Pingault V, Bondurand N, Kuhlbrodt K, Hermans-Borgmeyer I, Puliti A, Lemort N, Goossens M, Wegner M (1998) Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci USA 95:5161-5165.
25. Hu M, Whiting Theobald NL, Gardner PD (1994) Nerve growth factor increases the transcriptional activity of the neuronal nicotinic acetylcholine receptor β4 subunit promoter in transfected PC12 cells. J Neurochem 62:392-395.
26. Hu M, Bigger CB, Gardner PD (1995) A novel regulatory element of a nicotinic acetylcholine receptor gene interacts with a DNA-binding activity enriched in rat brain. J Biol Chem 270:4497-4502.
27. Jainchill JL, Aaronson SA, Todaro GJ (1969) Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol 4:549-553.
28. Kamachi Y, Sockanathan S, Liu Q, Breitman M, Lovell-Badge R, Kondoh H (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J 14:3510-3519.
29. Klebe RJ, Chen T, Ruddle FH (1970) Controlled production of proliferating somatic cell hybrids J Cell Biol 45:74-82.
30. Kuhlbrodt K, Herbarth B, Sock E, Hermans-Borgmeyer I, Wegner M (1998a) Sox10, a novel transcriptional modulator in glial cells. J Neurosci 18:237-250.
31. Kuhlbrodt K, Schmidt C, Sock E, Pingault V, Bondurand N, Goossens M, Wegner M (1998b) Functional analysis of Sox10 mutations found in human Waardenburg-Hirschsprung patients. J Biol Chem 273:23033-23038.
32. McDonough J, Deneris E (1997) β43′: an enhancer displaying neural-restricted activity is located in the 3′-untranslated exon of the rat nicotinic acetylcholine receptor β4 gene. J Neurosci 17:2273-2283.
33. McGehee DS, Role LW (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu Rev Physiol 57:521-546.
34. Milton NGN, Bessis A, Changeux J-P, Latchman DS (1996) Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors. Biochem J 317:419-423.
35. Monuki E, Kuhn R, Weinmaster G, Trapp B, Lemke G (1990) Expression and activity of the POU transcription factor SCIP. Science 249:1300-1303.
36. Monuki ES, Kuhn R, Lemke G (1993) Cell-specific action and mutable structure of a transcription factor effector domain. Proc Natl Acad Sci USA 90:9978-9982.
37. Nordeen S (1988) Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454-457.
38. Pevny LH, Lovell-Badge R (1997) Sox genes find their feet. Curr Opin Genet Dev 7:338-344.
39. Pingault V, Bondurand N, Kuhlbrodt K, Goerich DE, Prθhu M-O, Puliti A, Herbarth B, Hermans-Borgmeyer I, Legius E, Matthijs G, Amiel J, Lyonnet S, Ceccherini I, Romeo G, Smith JC, Read AP, Wegner M, Goossens M (1998) SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Nat Genet 18:171-173.
40. Pusch C, Hustert E, Pfeifer D, Südbeck P, Kist R, Roe B, Wang Z, Balling R, Blin N, Scherer G (1998) The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum Genet 103:115-123.
41. Role LW, Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16:1077-1085.
42. Schoepfer R, Conroy WG, Whiting P, Gore M, Lindstrom J (1990) Brain a-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron 5:35-48.
43. Southard-Smith EM, Kos L, Pavan WJ (1998) Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet 18:60-64.
44. Topp WC (1981) Normal rat cell lines deficient in nuclear thymidine kinase. Virology 113:408-411.
45. van de Wetering M, Oosterwegel M, van Norren K, Clevers H (1993) Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J 12:3847-3854.
46. Wegner M (1999) From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res 27:1409-1420.
47. Wright EM, Snopek B, Koopman P (1993) Seven new members of the Sox gene family expressed during development. Nucleic Acids Res 21:744.
48. Yang X, McDonough J, Fyodorov D, Morris M, Wang F, Deneris ES (1994) Characterization of an acetylcholine receptor α3 gene promoter and its activation by the POU domain factor SCIP/Tst-1. J Biol Chem 269:10252-10264.
49. Yang X, Fyodorov D, Deneris ES (1995) Transcriptional analysis of acetylcholine receptor α3 gene promoter motifs that bind Sp1 and AP2. J Biol Chem 270:8514-8520.
50. Yang X, Yang F, Fyodorov D, Wang F, McDonough J, Herrup K, Deneris E (1997) Elements between the protein-coding regions of the adjacent β4-α3 acetylcholine receptor genes direct neuron-specific expression in the central nervous system. J Neurobiol 28:311-324.
51. Yuan HB, Corbi N, Basilico C, Daily L (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9:2635-2645.
52. Zoli M, Le Novere N, Hill JA, Changeux J-P (1995) Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J Neurosci 15:1912-1939.
53. Zwilling S, K÷nig H, Wirth T (1995) High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J 14:1198-1208.