Topical application of vitamin A to oral leukoplakia: A clinical case series

Cancer

Volumn 86, Issue 6, 1999, Pages 921-927

  Epstein, Joel B ^a,b,d   Gorsky, Meir ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Dysplasia; Oral leukoplakia; Retinoids; Topical vitamin A

Indexed keywords

RETINOIC ACID; RETINOL;

ADULT; AGED; ARTICLE; BIOPSY; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; LEUKOPLAKIA; MALE; PRIORITY JOURNAL; REMISSION; TOBACCO; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; FEMALE; GINGIVAL NEOPLASMS; HUMANS; LEUKOPLAKIA, ORAL; LIP NEOPLASMS; MALE; MIDDLE AGED; TIME FACTORS; TONGUE NEOPLASMS; TREATMENT OUTCOME; VITAMIN A;

EID: 0033568235     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19990915)86:6<921::AID-CNCR5>3.0.CO;2-6     Document Type: Article

References (37)

1. World Health Organization Collaborating Center for Oral Precancerous Lesions. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978;46:518-39.
2. Axell T, Pindborg JJ, Smith CJ, van der Waal I. Oral white lesions with special reference to precancerous and tobacco-related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21, 1994. International Collaborative Group on Oral White Lesions. J Oral Pathol Med 1996;25:49-54.
3. Silverman S Jr., Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer 1984;53:563-8.
4. Pindborg JJ, Jolst O, Renstrup G, Roed-Petersen B. Studies on oral leukoplakia: a preliminary report on the period prevalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients. J Am Dent Assoc 1968;76:767-71.
5. Chu FWK, Silverman S Jr., Dedo HH. CO2 laser treatment of oral leukoplakia. Laryngoscope 1988;98:125-30.
6. Vedtofte P, Holmstrup P, Hjorting-Hansen E, Pindborg JJ. Surgical treatment of premalignant lesions of the oral mucosa. Int J Oral Maxillofac Surg 1987;16:656-64.
7. Chiesa F, Boracchi P, Tradati N, Rossi N, Costa L, Giardini R, et al. Risk of preneoplastic and neoplastic events in operated oral leukoplakias. Eur J Cancer (B), Oral Oncol 1993;29(B): 23-8.
8. Einhorn J, Wersall J. Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa. Cancer 1967;20:2189-93.
9. Schepman KP, van der Meij EH, Smeele LE, van der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998;34: 270-5.
10. Epstein JB, Gorsky M, Wong FLW, Millner A. Topical bleomycin for the treatment of dysplastic oral leukoplakia. Cancer 1998;83:629-34.
11. Silverman S Jr., Eisenberg E, Renstrup G. A study of the effect of high doses of vitamin A on oral leukoplakia (hyperkeratosis) including toxicity, liver function and skeletal metabolism. J Oral Thera Pharmacol 1965;2: 9-23.
12. Shah JP, Strong EW, DeCosse JJ, Itri L, Sellers P. Effects of retinoids on oral leukoplakia. Am J Surg 1983;146:466-70.
13. Koch HF. Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid. J Maxillofac Surg 1978;6:59-63.
14. Epstein JB, Scully C, Spinelli J. Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med 1992;21:160-3.
15. Lind PO. Malignant transformation in oral leukoplakia. Scand J Dent Res 1987;95:449-55.
16. Banoczy J, Sugar L Longitudinal studies in oral leukoplakias. J Oral Pathol 1972;1:265-72.
17. Amos B, Lotan R, Retinoid sensitive cells and cell lines. Methods Enzymol 1991;190:217-25.
18. Hong WK, Lippman SM, Hittelman WN, Lotan R. Retinoid chemoprevention of aerodigestive cancer: from basic research to the clinic. Clin Cancer Res 1995;1:677-86.
19. Sankaranarayanan R, Mathew B, Varghese C, Sudhakaran PR, Menon V, Jayadeep A, et al. Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment. Oral Oncol 1997;33:231-6.
20. Lippman SM, Batsakis JG, Toth BB, Weber RS, Lee JJ, Martin JW, et al. Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. N Engl J Med 1993; 328:15-20.
21. Garewal H. Chemoprevention of oral cancer: beta-carotene and Vitamin E in leukoplakia. Eur J Cancer Prev 1994;3: 101-7.
22. Bendich A. Carotenoids and the immune response. J Nutr 1989;119:112-5.
23. Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986;315:1501-5.
24. Shklar G, Schwartz J, Grau D, Trickler DP, Wallace KD. Inhibition of hamster buccal pouch carcinogenesis by 13-cis-retinoic acid. Oral Surg Oral Med Oral Pathol 1980;50: 45-52.
25. Lippman SM, Kesseler JF, Meyskens FL. Retinoids as preventive and therapeutic anticancer agents (part II). Cancer Treat Rep 1987;71:493-515.
26. Gorsky M, Raviv M. Efficacy of etretinate (Tigason) in symptomatic oral lichen planus. Oral Surg Oral Med Oral Pathol 1992;73:52-5.
27. Krishnaswamy K, Prasad MPR, Krishna TP, et al. A case study of nutrient intervention of oral precancerous lesions in India. Oral Oncol 1995;31B:41-8.
28. Kaugars GE, Silverman S Jr., Lovas JGI, Brandt RB, Riley WT, Dao Q, et al. A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. Oral Surg Oral Med Oral Pathol 1994;78:462-8.
29. Kaugars GE, Silverman S Jr., Lovas JGL, Thompson JS, Brandt RB, Singh VN. Use of antioxidant supplements in the treatment of human oral leukoplakia. Review of the literature and current studies. Oral Surg Oral Med Oral Pathol 1996;81:5-14.
30. Del Prete A, Ferrante M, Troisi S, Mele V, Reccia R, Sebastiani A. Postsurgical dyskeratosis treated with topical and parenteral administration of vitamin A. Ophthalmologica 1997;211:101-3.
31. Markowska J, Wiese E. Dystrophy of the vulva locally treated with 13-cis retinoic acid. Neoplasma 1992;39:133-5.
32. Meyskens FL Jr., Alberts DS, Manetta A, Chu J. Prevention of cervical dysplasia [meeting abstract]. Presented at the Second International Conference: Antioxidants, Vitamins, and Beta-Carotene in Disease Prevention, Berlin, Germany, October 10-12, 1994:27.
33. Muller SA, Belcher RW, Esterly NB, Lochner JC, Miller JS, Roenigk H Jr., et al. Keratinizing dermatoses. Combined data from four centers on short-term topical treatment with tretinoin. Arch Dermatol 1977;113:1052-4.
34. Solberg K, Hersle K, Mobacken H, Thilander H. Topical tretinoin therapy and oral lichen planus. Arch Dermatol 1979;115:716-8.
35. Raque CJ, Biondo RV, Keeran MG, Honeycutt WM, Jansen GT. Snuff dippers keratosis (snuff-induced leukoplakia). South Med J 1975;68:565-8.
36. Tradati N, Chiesa R, Rossi N, Grigolato R, Formelli F, Costa A, et al. Successful topical treatment of oral lichen planus and leukoplakia with fenretinide (4-HPR). Cancer Lett 1994; 76:109-11.
37. Tradati N, Grigolat R, Calabrese L, Costa L, Giugliano G, Morelli F, et al. Oral leukoplakias: to treat or not? Oral Oncol 1997;33:317-21.