Models for antigen receptor gene rearrangement. I. Biased receptor editing in B cells: Implications for allelic exclusion

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 1793-1798

  Mehr, Ramit ^a   Shannon, Michele ^a   Litwin, Samuel ^b  

^a PRINCETON UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; GENE REARRANGEMENT; IMMUNOGENETICS; PRIORITY JOURNAL; SIMULATION;

ALLELES; ANIMALS; B-LYMPHOCYTES; COMPUTER SIMULATION; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, B-LYMPHOCYTE; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; MODELS, IMMUNOLOGICAL; PROBABILITY; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; RNA EDITING; STOCHASTIC PROCESSES;

EID: 0033566925     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999.
2. Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
3. Han, S., S. R. Dillon, B. Zheng, M. Shimoda, M. S. Schlissel, and G. Kelsoe. 1997. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278:301.
4. Radic, M. Z., and M. Zouali. 1996. Receptor editing, immune diversification, and self-tolerance. Immunity 5:505.
5. Prak, E.-L., M. Trounstine, D. Huszar, and M. Weigert. 1994. Light chain editing in κ-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180:1805.
6. Prak, E.-L., and M. Weigert. 1995. Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182:541.
7. Chen, C., E.-L. Prak, and M. Weigert. 1997. Editing in disease-associated autoantibodies. Immunity 6:97.
8. Pewzner-Jung, Y., D. Friedmann, E. Sonoda, S. Jung, K. Rajewsky, and D. Eilat. 1998. B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J. Immunol. 161:4634.
9. Langman, R. E., and M. Cohn. 1992. How might the κ/λ ratio expressed by antigen-unselected B cells be explained? Res. Immunol. 143:804.
10. Zou, Y.-R., S. Takeda, and K. Rajewsky. 1993. Gene targeting in the Igκ locus: efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ. EMBO J. 12:811.
11. ten Boekel, E. F., F. Melchers, and A. Rolink. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013.
12. Langman, R. E., and M. Cohn. 1995. The proportion of B cell subsets expressing κ and λ light chains changes following antigenic selection. Immunol. Today 16: 141.
13. Arakawa, H., T. Shimizu, and S. Takeda. 1996. Re-evaluation of the probabilities for productive rearrangements on the κ and λ loci. Int. Immunol. 8:91.
14. Takeda, S., E. Sonoda, and H. Arakawa. 1996. The κ/λ ratio of immature B cells (letter). Immunol. Today 17:200.
15. Langman, R. E., and M. Cohn. 1996. Reply to letter concerning "the κ/λ ratio of immature B cells". Immunol. Today 17:200.
16. Ramsden, D. A., and G. E. Wu. 1991. Mouse κ light-chain recombination signal sequences mediate recombination more frequently than do those of a λ light chain. Proc. Natl. Acad. Sci. USA 88:10721.
17. Coleclough, C. 1992. 47th forum in immunology: what determines the κ/λ ratio. Res. Immunol. 143:838.
18. Pelavin, P. I. 1996. Why B cells express a single antigen receptor: a probabilistic model. Senior thesis, Department of Molecular Biology, Princeton University, Princeton, NJ.
19. Coleclough, C., R. P. Perry, K. Karjalainen, and M. Weigert. 1981. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290:372.
20. Wood, D. L., and C. Coleclough. 1984. Different joining region J elements of the murine κ immunoglobulin light chain locus are used at markedly different frequencies. Proc. Natl. Acad. Sci. USA 81:4756.
21. + B cells. J. Clin. Invest. 99:1614.
22. DeBoer, R. J., and A. S. Perelson. 1993. How diverse should the immune system be? Proc. R. Soc. Lond. Ser. B 252:343.
23. Nemazee, D. 1996. Antigen receptor 'capacity' and the sensitivity of self-tolerance. Immunol. Today 17:25.
24. Nemazee, D. 1998. Theoretical limits to massive receptor editing in immature B cells. In Current Topics in Microbiology and Immunology, Vol. 229, Somatic Diversification of Immune Responses. G. Kelsoe and M. F. Flajnik, eds. Springer, Berlin, p. 163.
25. Mostoslavsky, R., N. Singh, A. Kirillov, R. Pelanda, H. Cedar, A. Chess, and Y. Bergman. 1998. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12:1801.