Distinct patterns of neuropeptide gene expression in the lateral hypothalamic area and arcuate nucleus are associated with dehydration- induced anorexia

Journal of Neuroscience

Volumn 19, Issue 14, 1999, Pages 6111-6121

  Watts, Alan G ^a   Sanchez Watts, Graciela ^a   Kelly, Andrea B ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Anorexia; Arcuate nucleus; Corticotropin releasing hormone; Feeding behavior; Glucocorticoid; Lateral hypothalamus; Leptin; Neuropeptides; Paraventricular nucleus

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; INSULIN; LEPTIN; MESSENGER RNA; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTENSIN; PROOPIOMELANOCORTIN;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANOREXIA; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; BRAIN MAPPING; CONTROLLED STUDY; DEHYDRATION; FOOD INTAKE; GENE EXPRESSION; LATERAL HYPOTHALAMUS; MALE; NEUROANATOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; TISSUE DISTRIBUTION;

EID: 0033566009     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-14-06111.1999     Document Type: Article

References (51)

1. Brady LS, Smith MA, Gold PW, Herkenham M (1990) Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52:441-447.
2. Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T (1998) Hypocretin/ orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 402:460-474.
3. Champagne D, Beaulieu J, Drolet G (1998) CRFergic innervation of the paraventricular nucleus of the rat hypothalamus: a tract-tracing study. J Neuroendocrinol 10:119-131.
4. Drouin J, Goodman HM (1980) Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences. Nature 288:610-613.
5. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK (1998a) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385.
6. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK (1998b) Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402:442-459.
7. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS (1998a) Unraveling the central-nervous-system pathways underlying responses to leptin. Nat Neurosci 1:445-450.
8. Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB (1998b) Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395:535-547.
9. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB (1998c) Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 95:741-746.
10. Elmquist JK, Elias CF, Saper CB (1999) From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:1-20.
11. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168.
12. Frim DM, Robinson BG, Pasieka KB, Majzoub JA (1990) Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Am J Physiol 258:E686-E692.
13. Gold PW (1973) Hypothalamic obesity: the myth of the ventromedial nucleus. Science 182:488-490.
14. Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B (1998) Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 18:559-572.
15. Hatton GI, Bennett CT (1970) Satiation of thirst and termination of drinking roles of plasma osmolality and absorption. Physiol Behav 5:479-487.
16. Heinrichs SC, Menzaghi F, Pich EM, Hauger RL, Koob GF (1993) Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide-Y. Brain Res 611:18-24.
17. Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD (1995) Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 38:3454-3461.
18. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141.
19. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88:10931-10935.
20. Kay-Nishiyama C, Watts AG (1999) Dehydration modifies somal CRH immunoreactivity in the rat hypothalamus: an immunocytochemical study in the absence of colchicine. Brain Res 822:251-255.
21. Kelly AB, Watts AG (1996) The mediation of dehydration-induced peptidergic gene expression in the rat lateral hypothalamic area by forebrain afferent projections. J Comp Neurol 370:231-246.
22. Kelly AB, Watts AG (1998) The region of the pontine parabrachial nucleus is a major target of dehydration-sensitive CRH neurons in the rat lateral hypothalamic area. J Comp Neurol 394:48-63.
23. Kislauskis E, Dobner PR (1990) Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells. Neuron 4:783-795.
24. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76.
25. Larhammar D, Ericsson A, Persson H (1987) Structure and expression of the rat neuropeptide Y gene. Proc Natl Acad Sci USA 84:2068-2072.
26. Larsen PJ, Hay-Schmidt A, Mikkelsen JD (1994) Efferent connections from the lateral hypothalamic region and the lateral preoptic area to the hypothalamic paraventricular nucleus of the rat. J Comp Neurol 342:299-319.
27. Levine AS, Kneip J, Grace M, Morley JE (1983) Effect of centrally administered neurotensin on multiple feeding paradigms. Pharmacol Biochem Behav 18:19-23.
28. Moga MM, Saper CB, Gray TS (1990) Neuropeptide organization of the hypothalamic projection to the parabrachial nucleus in the rat. J Comp Neurol 295:662-682.
29. Morley JE (1987) Neuropeptide regulation of appetite and weight. Endoer Rev 8:256-287.
30. O'Shea RD, Gundlach AL (1995) NPY mRNA and peptide immunoreactivity in the arcuate nucleus are increased by osmotic stimuli: correlation with dehydration anorexia. Peptides 16:1117-1125.
31. Sahu A (1998) Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 139:795-798.
32. Sawchenko PE (1998) Towards a new neurobiology of energy balance, appetite and obesity: the anatomists weigh in. J Comp Neurol 402:435-441.
33. Schwartz MW, Dallman MF, Woods SC (1995) Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 269:R949-R957.
34. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106.
35. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG (1997) Leptin increases hypothalamic proopiomelanocortin messenger-RNA expression in the rostral arcuate nucleus. Diabetes 46:2119-2123.
36. Stanley BG, Leibowitz SF (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 82:3940-3943.
37. Stricker EM (1990) Homeostatic origins of ingestive behavior. In: Neurobiology of food and fluid intake. Handbook of behavioral neurobiology, Vol 10 (Stricker EM, ed), pp 45-60. New York: Plenum.
38. Swanson LW (1987) The hypothalamus. In: Handbook of chemical neuroanatomy, Vol 5 (Bjorklund A, Hökfelt T, Swanson LW, eds), pp 1-124. Amsterdam: Elsevier Science Publishers.
39. Swanson LW (1992) Brain maps: structure of the rat brain. Amsterdam: Elsevier Science Publishers.
40. Tanimura SM, Watts AG (1998) Corticosterone can facilitate as well as inhibit CRH gene expression in the rat hypothalamic paraventricular nucleus. Endocrinology 139:3830-3837.
41. Thiele TE, van Dijk G, Yagaloff KA, Fisher SL, Schwartz M, Burn P, Seeley RJ (1998) Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am J Physiol 274:R248-R254.
42. Watts AG (1992) Osmotic stimulation differentially affects cellular corticotropin releasing-hormone and neurotensin/neuromedin N mRNA levels in the lateral hypothalamic area and central nucleus of the amygdala. Brain Res 581:208-216,
43. Watts AG (1996) The impact of physiological stimulation on the expression of corticotropin-releasing hormone and other neuropeptide genes. Front Neuroendocrinol 17:281-326.
44. Watts AG (1999) Dehydration-associated anorexia: development and rapid reversal. Physiol Behav 65:871-878.
45. Watts AG, Sanchez-Watts G (1995a) A cell-specific role for the adrenal gland in regulating CRH mRNA levels in rat hypothalamic neurosecretory neurones after cellular dehydration. Brain Res 687:63-70.
46. Watts AG, Sanchez-Watts G (1995b) Physiological regulation of peptide messenger RNA colocalization in rat hypothalamic paraventricular medial parvicellular neurons. J Comp Neurol 352:501-514.
47. Watts AG, Sanchez-Watts G (1998) Hunger- and anorexia-associated patterns of neuropeptide gene expression in the rat hypothalamus. Soc Neurosci Abstr 24:449.
48. Watts AG, Kelly AB, Sanchez-Watts G (1995) Neuropeptides and thirst: the temporal response of corticotropin-releasing hormone and neurotensin/neuromedin N gene expression in rat limbic forebrain neurons to drinking hypertonic saline. Behav Neurosci 109:1146-1157.
49. Watts AG, Sanchez-Watts G, Kelly AB, Zheng JQ, Kay-Nishiyama C (1998) CRH in the lateral hypothalamic area, paraventricular, and parabrachial nuclei: a potential integrative network for generating anorexia. Physiologist 41:371.
50. Winn P (1995) The lateral hypothalamus and motivated behavior: an old syndrome reassessed and a new perspective gained. Curr Dir Psychol Sci 4:182-187.
51. Woods SC, Seeley RJ, Porte Jr D, Schwartz MW (1998) Signals that regulate food intake and energy homeostasis. Science 280:1378-1383.