Linkers designed to intercalate the double helix greatly facilitate DNA alkylation by triplex-forming oligonucleotides carrying a cyclopropapyrroloindole reactive moiety

Nucleic Acids Research

Volumn 27, Issue 14, 1999, Pages 2931-2937

  Dempcy, Robert O ^a   Kutyavin, Igor V ^a   Mills, Alan G ^a   Lukhtanov, Eugeny A ^a   Meyer, Rich B ^a  

^a Nanogen Inc USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE; CYCLOPROPAPYRROLOINDOLE SUBUNIT; DNA; INDOLE DERIVATIVE; OLIGONUCLEOTIDE; RACHELMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA ALKYLATION; DNA HELIX; PRIORITY JOURNAL;

ACRIDINES; ADENINE; ALKYLATION; BASE SEQUENCE; BINDING SITES; CYCLOPROPANES; DNA; DRUG DESIGN; INDOLES; INTERCALATING AGENTS; LEUCOMYCINS; MODELS, CHEMICAL; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 0033565952     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/27.14.2931     Document Type: Article

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