Interleukin-9 regulates NF-κB activity through BCL3 gene induction

Blood

Volumn 93, Issue 12, 1999, Pages 4318-4327

  Richard, Mélisande ^b   Louahed, Jamila ^b   Demoulin, Jean Baptiste ^b   Renauld, Jean Christophe ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; INTERLEUKIN 9;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REGULATORY MECHANISM; T LYMPHOCYTE;

EID: 0033564959     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.12.4318.412k09_4318_4327     Document Type: Article

References (43)

1. Ohno H, Takimoto O, McKeithan W: The candidate protooncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60:991, 1990
2. Nolan GP, Fujita T, Bhatia K, Huppi C, Liou H, Scott ML, Baltimore D: The bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 13:3557, 1993
3. Schwartz EM, Krimpenfort P, Berns A, Verma IM: Immunological defects in mice with a targeted disruption in bcl-3. Genes Dev 11:187, 1997
4. Franzoso G, Carlson L, Scharton-Kersten T, Shores EW, Epstein S, Grinberg A, Tran T, Shacter E, Leonardi A, Anver M, Love P, Sher A, Siebenlist U: Critical roles for the Bcl-3 oncoprotein in T-cell mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity 6:479, 1997
5. Bours V, Villalobos J, Burd PR, Kelly K, Siebenlist U: Cloning of a mitogen-inducible gene encoding a KB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature 348:76, 1990
6. Baldwin AS: The NF-κB and IκB proteins: New discoveries and insights. Annu Rev Immunol 14:649, 1996
7. Baeuerle PA, Baltimore D: NF-κB: Ten years after. Cell 87:13, 1996
8. Finco TS, Baldwin AS: Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis. Immunity 3:263, 1995
9. May MJ, Ghosh S: Signal transduction through NF-κB. Immunol Today 19:80, 1998
10. Zabel U, Baeuerle PA: Purified human IκB can rapidly dissociate the complex of NF-κB transcription factor with its cognate DNA. Cell 61:255, 1990
11. Haskill S, Beg AA, Tompkins SM, Morris JS, Yurocho AD, Sampson-Johannes A, Mondai K, Ralph P, Baldwin ASJ: Characterization of an immediate-early gene induced in adherent monocytes that encodes I κ B-like activity. Cell 65:1281, 1991
12. Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U: The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature 359:339, 1992
13. Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U: The oncoprolein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers. Cell 72:729, 1993
14. Zhang Q, Didonato JA, Karin M, McKeithan TW: bcl3 encodes a nuclear protein which can alter the subcellular location of NF-κB proteins. Mol Cell Biol 14:3915, 1994
15. Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S: IκB-beta regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573, 1995
16. Wulczyn FG, Naumann M, Scheidereit C: Candidate protooncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB. Nature 358:597, 1992
17. Fujita T, Nolan GP, Liou H, Scott ML, Baltimore D: The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev 7:1354, 1993
18. Watanabe N, Iwamura T, Shinoda T, Fujita T: Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: Generation of NF-kB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. EMBO J 16:3609, 1997
19. Kang SM, Tran AC, Grilli M, Lenardo MJ: NF-κB subunit regulation in nontransformed CD4+ T lymphocytes. Science 256:1452, 1992
20. Fujita T, Nolan GP, Ghosh S, Baltimore D: Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev 6:775, 1992
21. Kretzschmar M, Meisterernst M, Scheidereit C, Li G, Roeder RG: Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes Dev 6:761, 1992
22. Kerr LD, Duckett CS, Wamsley P, Zhang Q, Chiao P, Nabel G, McKeithan TW, Baeuerle PA, Verma IM: The proto-oncogene bcl-3 encodes an IκB protein. Genes Dev 6:2352, 1992
23. Bhatia K, Huppi K, McKeithan T, Siwarski D, Mushinski JF, Magrath I: Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes. Oncogene 6:1569, 1991
24. Uyttenhove C, Simpson R, Van Snick J: Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity. Proc Natl Acad Sci USA 85:6934, 1988
25. Renauld J-C, Van Snick J: Interleukin-9, in Thompson A (ed): The Cytokine Handbook (ed 3). San Diego, CA, Academic, 1998, p 313
26. Renauld J-C, Vink A, Louahed J, Van Snick J: IL-9 is a major anti-apoptotic factor for thymic lymphomas. Blood 85:1300, 1995
27. Renauld J-C, van der Lugt N, Vink A, van Roon M, Godfraind C, Warnier G, Merz H, Feller A, Berns A, Van Snick J: Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 9:1327, 1994
28. Nicolaides N, Holroyd KJ, Ewart SL, Eleff SM, Kiser MB, Dragwa CR, Sullivan CD, Grasso L, Zhang LY, Messier CJ, Zhou T, Kleeberger SR, Buetow KH, Levitt RC: Interleukin 9: A candidate gene for asthma. Proc Natl Acad Sci USA 94:13175, 1997
29. Louahed J, Kermouni A, Van Snick J, Renauld J-C: IL-9 induces expression of granzymes and high affinity IgE receptor in marine T helper clones. J Immunol 154:5061, 1995
30. Mizushima S, Nagata S: pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res 18:5322, 1990
31. Demoulin J-B, Uyttenhove C, Van Roost E, de Lestré B, Donckers D, Van Snick J, Renauld J-C: A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16:4710, 1996
32. Druez C, Coulie P, Uyttenhove C, Van Snick J: Functional and biochemical characterization of mouse P40/IL-9 receptors. J Immunol 145:2494, 1990
33. Ausubel F, Brent R, Kingston R, Moore D, Seidman J, Smith J, Struhl K: Current Protocols in Molecular Biology, vol 1 and 2. New York, NY, Wiley, 1993
34. Hubank M, Schatz DG: Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res 22:5640, 1994
35. Van Snick J, Goethals A, Renauld J-C, Van Roost E, Uyttenhove C, Rubira MR, Moritz RL, Simpson RJ: Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). J Exp Med 169:363, 1989
36. Schreiber E, Matthias P, Müller M, Schaffner W: Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res 17:6419, 1989
37. De Smet C, Courtois S, Faraoni I, Lurquin C, Szikora J-P, De Backer O, Boon T: Involvement of two Ets binding sites in the transcriptional activation of the MAGE1 gene. Immunogenetics 42:282, 1995
38. Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck R-P, Bravo R, Kelly K, Siebenlist U: A novel mitogen-inducible gene product related to p50/p105-NF-κB participates in transactivation through a KB site. Mol Cell Biol 12:685, 1992
39. Philippe M, Larondelle Y, Lemaigre F, Mariame B, Delhez H, Mason P, Luzzatto L, Rousseau GG: Promoter function of the human glucose-6-phosphate deshydrogenase gene depends on two GC boxes that are cell specifically controlled. Eur J Biochem 226:377, 1994
40. Inoue J, Takahara T, Akizawa T, Hino O: Bcl-3, a member of the IκB proteins, has distinct specificity towards the ReI family of proteins. Oncogene 8:2067, 1993
41. Franzoso G, Bours V, Azarenko V, Park S, Tomita-Yamaguchi M, Kanno T, Brown K, Siebenlist U: The oncoprotein Bcl-3 can facilitate NF-κB mediated transactivation by removing inhibiting p50 homodimers from select KB sites. EMBO J 12:3893, 1993
42. Pan J, McEver RP: Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-κB/Rel family. J Biol Chem 270:23077, 1995
43. Caamano JH, Perez P, Lira SA, Bravo R: Constitutive expression of Bcl-3 in thymocytes increases the DNA binding of NF-κB1 (p50) homodimers in vivo. Mol Cell Biol 16:1342, 1996