Cutting edge: Silencing virus-specific cytotoxic T cell-mediated immune recognition by differential splicing: A novel implication of RNA processing for antigen presentation

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 6963-6966

  Kienzle, Norbert ^a   Sculley, Tom B ^a   Greco, Sonia ^a   Khanna, Rajiv ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE RNA SPLICING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIRUS INFECTIVITY; VIRUS TRANSCRIPTION;

ANTIGEN PRESENTATION; CELL LINE; CELL LINE, TRANSFORMED; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; HERPESVIRUS 4, HUMAN; HUMANS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 0033564695     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Powis, S. H. 1998. Lessons from an age-old war. Nat. Med. 4:887.
2. Rickinson, A. B., and D. J. Moss. 1997. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu. Rev. Immunol. 15:405.
3. Sadler, R. H., and N. Raab-Traub. 1995. Structural analyses of the Epstein-Barr virus BamHI A transcripts. J. Virol. 69:1132.
4. Hitt, M. M., M. J. Allday, T. Hara, L. Karran, M. D. Jones, P. Busson, T. Tursz, I. Emberg, and B. E. Griffin. 1989. EBV gene expression in an NPC-related tumour. EMBO J. 8:2639.
5. Kienzle, N., T. B. Sculley, L. Poulsen, M. Buck, S. Cross, N. Raab-Traub, and R. Khanna. 1998. Identification of a cytotoxic T-lymphocyte response to the novel BARFO protein of Epstein-Barr virus: a critical role for antigen expression. J. Virol. 72:6614.
6. Pope, J. H. 1968. Establishment of cell lines from Australian leukaemic patients: presence of a herpes-like virus. Aust. J. Exp. Biol. Med. Sci. 46:643.
7. Baer, R., A. T. Bankier, M. D. Biggin, P. L. Deininger, P. J. Farrell, T. J. Gibson, G. Hatfull, G. S. Hudson, S. C. Satchwell, C. Seguin, P. S. Tuffnell, and B. G. Barrell. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310:207.
8. Kienzle, N., D. B. Young, D. Liaskou, M. Buck, S. Greco, and T. B. Sculley. 1999. Intron retention may regulate expression of Epstein-Barr virus nuclear antigen 3 family genes. J. Virol. 73:1195.
9. Moss, D. J., I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, and T. B. Sculley. 1988. Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants. Nature 331:719.
10. Fries, K. L., T. B. Sculley, J. Webster-Cyriaque, P. Rajadurai, R. H. Sadler, and N. Raab-Traub. 1997. Identification of a novel protein encoded by the BamHI A region of the Epstein-Barr virus. J. Virol. 71:2765.
11. Guilloux, Y., S. Lucas, V. G. Brichard, A. Van Pel, C. Viret, E. De Plaen, F. Brasseur, B. Lethe, F. Jotereau, and T. Boon. 1996. A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene. J. Exp. Med. 183:1173.
12. Lupetti, R., P. Pisarra, A. Verrecchia, C. Farina, G. Nicolini, A. Anichini, C. Bordignon, M. Sensi, G. Parmiani, and C. Traversari. 1998. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J. Exp. Med. 188:1005.